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Nagham Badreddine

As seen in: BioRxiv, Cell Reports, HAL
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Articles

Early Alterations of Motor Learning and Corticostriatal Network Activity in a Huntington's Disease Mouse Model

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By Nagham Badreddine, Florence Appaix, GIPSA Pôle Géométrie, Sophie Achard
| HAL
Article Dans Une Revue European Journal of Neuroscience Année : 2025 Early Alterations of Motor Learning and Corticostriatal Network Activity in a Huntington's Disease Mouse Model Domaines Fichier principal 2024.10.07.616936v1.full.pdf (1.31 Mo) Télécharger le fichier Origine Fichiers produits par l'(les) auteur(s) hal-05053617 , version 1 (12-06-2025) HAL Id : hal-05053617 , version 1 DOI : 10.1111/ejn.70056 Nagham Badreddine, Florence Appaix, Guillaume Jean-Paul Claude Becq, Sophie Achard,...
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Early alterations of motor learning and corticostriatal network activity in a Huntington's disease mouse model

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By Nagham Badreddine, Florence Appaix, Guillaume Becq, Sophie Achard
| BioRxiv
Abstract Huntington's disease (HD) is a neurodegenerative disorder that presents motor, cognitive and psychiatric symptoms as it progresses. Prior to motor symptoms onset, alterations and dysfunctions in the corticostriatal projections have been described along with cognitive deficits, but the sequence of early defects of brain circuits is largely unknown. There is thus a crucial need to identify early alterations that precede symptoms and that could be used as potential early disease markers.
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Somatostatin interneurons select dorsomedial striatal representations of the initial learning phase

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By Gisela Zalcman, Nagham Badreddine, Florence Appaix, Sanziana Rotariu
| BioRxiv
Abstract The dorsomedial striatum (DMS) is an associative node involved in the adaptation of ongoing actions to the environmental context and in the initial formation of motor sequences. In early associative or motor learning phases, DMS activity shows a global decrease in neuron firing, eventually giving rise to a select group of active cells, whose number is correlated with animal performance.
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