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Nairen Zheng on Muck Rack

Nairen Zheng

As seen in: Nature
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Articles

m 6 A modification by METTL3 enhances BIRC6 translation to promote liver tumorigenesis

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By Chenliang Wang, Lang Song, Shixun Han, Jie J. Cao, Zezhen Lu, Mei Tang, Qi Zhou, Xiaolei Cao, Bing Wu, Yuchao Cao, Xiner Ying, Yijie Guo, Xueli Bai, Tingbo Liang, Jun Qin, Xin-Hua Feng, Jianzhao Liu, Bin Zhao, Nairen Zheng
| Nature Verified
Abstract N6-methyladenosine (m6A) is the most prevalent internal modification of mRNA and is frequently dysregulated in cancer. However, the roles of m6A and its modifiers, such as the methyltransferase METTL3, remain controversial in primary tumors. We report that METTL3 is upregulated in the highly proliferative human S2 and mouse M2 subtypes of hepatocellular carcinoma (HCC).
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