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Nalinda P. Wickramasinghe on Muck Rack

Nalinda P. Wickramasinghe

As seen in: The Journal of Biological Chemistry
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Articles

Structure-based stabilization of insulin as a therapeutic protein assembly via enhanced aromatic-aromatic interactions

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By Nischay K. Rege, Nalinda P. Wickramasinghe, Alisar N. Tustan, Vivien C. Yee
| The Journal of Biological Chemistry Verified
Key contributions to protein structure and stability are provided by weakly polar interactions, which arise from asymmetric electronic distributions within amino acids and peptide bonds. Of particular interest are aromatic side chains whose directional π-systems commonly stabilize protein interiors and interfaces. Here, we consider aromatic–aromatic interactions within a model protein assembly: the dimer interface of insulin.
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­­­­­Structure-Based Stabilization of Insulin as a Therapeutic Protein Assembly via Enhanced Aromatic-Aromatic Interactions

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By Nischay K. Rege, Nelson Phillips, Nalinda P. Wickramasinghe, Alisar N. Tustan
| The Journal of Biological Chemistry Verified
Key contributions to protein structure and stability are provided by weakly polar interactions, which arise from asymmetric electronic distributions within amino acids and peptide bonds. Of particular interest are aromatic side chains whose directional π systems commonly stabilize protein interiors and interfaces. Here, we consider aromatic-aromatic interactions within a model protein assembly: the dimer interface of insulin.
Open in Who Shared Issue with article?
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