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Nandish Khanra on Muck Rack

Nandish Khanra

As seen in: Nature, Science Magazine, BioRxiv, Cell Reports
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Articles

Structures of partially occupied hetero-tetramers provide insight into kainate receptor activation and desensitization

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By Nandish Khanra, Alexa Strauss, Laura Wasielewski, Joel R. Meyerson, Andreas Reiner, Joshua Levitz, Sophie Lenze
| Nature Verified
Abstract Kainate receptors (KARs) are critical mediators and modulators of synaptic transmission which undergo rapid activation and desensitization upon binding of the neurotransmitter glutamate. Under various physiological and pharmacological conditions agonist binding likely occurs to only a subset of subunits within these tetrameric receptors, motivating an analysis of the functional and conformational effects of partial versus complete ligand occupancy.
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Structure of the human TWIK-2 potassium channel and its inhibition by pimozide

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By Nandish Khanra, Chongyuan Wang, Bryce D. Delgado, Stephen Long
| BioRxiv
Abstract The potassium channel TWIK-2 is crucial for ATP-induced activation of the NLRP3 inflammasome in macrophages. The channel is a member of the two-pore domain potassium (K2P) channel superfamily and an emerging therapeutic target to mitigate severe inflammatory injury involving NLRP3 activation. We report the cryo-EM structure of human TWIK-2.
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CD19 CAR antigen engagement mechanisms and affinity tuning

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By Changhao He, Jorge Mansilla-Soto, Nandish Khanra, Mohamad Hamieh, Derek Shore, William Rice, George Khelashvili, Michel Sadelain, Joel R. Meyerson, Victor Bustos, Alice J. Paquette, Andreina Garcia Angus
| Science Magazine Verified
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