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Nanna Torpe on Muck Rack

Nanna Torpe

As seen in: Cell Press
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Articles

A Protein Disulfide Isomerase Controls Neuronal Migration through Regulation of Wnt Secretion

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By Biotech Research, Sandeep Gopal, Nanna Torpe, Oguzhan Baltaci
| Cell Press Verified
Highlights • PDI-1, a protein disulfide isomerase, regulates neuron migration • PDI-1 functions in EGL-20/Wnt-producing cells to control neuron migration • Protein disulfide isomerases are evolutionarily conserved regulators of Wnt secretion Summary Appropriate Wnt morphogen secretion is required to control animal development and homeostasis. Although correct Wnt globular structure is essential for secretion, proteins that directly mediate Wnt folding and maturation remain uncharacterized.
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