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Naoto T Ueno on Muck Rack

Naoto T Ueno

Honolulu
As seen in: Nature, Wiley Online Library, The Oncologist, Women's Health (SAGE Journal), JAMA Oncology, Science Magazine, The Lancet, Honolulu Star-Advertiser, Chinese Clinical Oncology, ONCOLOGY journal and
Director, NCI-designated University of Hawai’i Cancer Center @UHCancerCenter, Breast Med Onc. Cancer Survivor. www.uhcancercenter.org/ueno-naoto
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Articles

ZO-1 shuttles between apical junctional complexes and podosomes by riding ERK activation waves

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By Sayuki Hirano, Yohei Kondo, Asayuki Kitajima, Noriyuki Kinoshita, Tetsuhisa Otani, Mikio Furuse, Naoto T Ueno, Kazuhiro Aoki
| Nature Verified
Abstract Collective cell migration is essential in various physiological processes, including embryonic development, wound healing, and cancer metastasis. However, the mechanisms by which individual cells achieve coordinated movement remain elusive. Here, we demonstrate that zonula occludens-1 (ZO-1), a scaffolding protein of tight junctions (TJs), dynamically translocates to form cell–extracellular matrix (ECM) adhesion complexes, podosomes, at the basal cell surface during migration.
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Pervasive enhanced transcription in inflammatory breast cancer tumors and PBMCs impacts RNA splicing and intronic RNAs in plasma

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By Dennis Wylie, Masahiro Yoshida, Wouter J. Holman, Xiaoping Wang, Jun Yao, Hengyi Xu, Elizabeth A Ferrick-Kiddie, Toshiaki Iwase, Savitri Krishnamurthy, Naoto T Ueno, Alan M. Lambowitz
| Science Magazine Verified
Abstract Inflammatory breast cancer (IBC), an aggressive and lethal breast cancer subtype, lacks unequivocal genomic differences or robust biomarkers that differentiate it from non-IBC. Here, TGIRT-seq revealed myriad differences in tumors, PBMC, and plasma RNAs that distinguished IBC patients from non-IBC patients and healthy donors across different tested breast cancer subtypes.
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ATR inhibition potentiates the antitumor efficacy of HER3-DXd in HER3-positive/HR-positive breast cancer by increasing DNA damage

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By Xuemei Xie, Jangsoon Lee, Young Gi, Thanasis Poullikkas, Jon A. Fuson, Pang-Dian Fan, Jami Fukui, Debu Tripathy, Naoto T Ueno
| Nature Verified
Abstract Endocrine resistance remains a major challenge in hormone receptor–positive (HR+) breast cancer (BC), where up to 70% of tumours overexpress HER3, a receptor associated with poor prognosis and therapeutic resistance. HER3-DXd (patritumab deruxtecan) is currently under clinical investigation for HER3-expressing metastatic BC. However, strategies to further enhance its efficacy, particularly in endocrine therapy–resistant settings, are urgently needed.
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