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Natalia Litbarg on Muck Rack

Natalia Litbarg

As seen in: The Journal of Biological Chemistry
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Articles

Repeated exposure of epithelial cells to apoptotic cells induces the specific selection of an adaptive phenotype: Implications for tumorigenesis

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By Lanfei Feng, Snezana Vujicic, Michael E Dietrich, Natalia Litbarg
| The Journal of Biological Chemistry Verified
The consequences of apoptosis extend beyond the mere death of the cell. We have shown that receptor-mediated recognition of apoptotic target cells by viable kidney proximal tubular epithelial cells (PTECs) inhibits PTEC proliferation, growth, and survival. Here, we tested the hypothesis that continual exposure to apoptotic targets can induce a phenotypic change in responding PTECs, as in other instances of natural selection.
Open in Who Shared Issue with article?

Repeated Exposure of Epithelial Cells to Apoptotic Cells Induces the Specific Selection of an Adaptive Phenotype: Implications for Tumorigenesis

|
By Lanfei Feng, Snezana Vujicic, Michael E Dietrich, Natalia Litbarg
| The Journal of Biological Chemistry Verified
The consequences of apoptosis extend beyond mere death of the cell. We have shown that receptor-mediated recognition of apoptotic target cells by viable kidney proximal tubular epithelial cells (PTECs) inhibits PTEC proliferation, growth, and survival. Here we tested the hypothesis that continual exposure to apoptotic targets can induce a phenotypic change in responding PTECs, as in other instances of natural selection.
Open in Who Shared Issue with article?
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