Natalie de Souza on Muck Rack

Natalie de Souza

  • Professor, ETH Zurich
New York
As seen in: Nature, Nature Methods, Cell Press, Cell Reports Medicine, New York Review of Books, Cabinet Magazine, The New York Review of Books
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Articles

Imaging mass cytometry reveals functional and immunological changes during type 1 diabetes progression in human pancreata

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By Nathan Steenbuck, Nicolas Damond, Stefanie Engler, Irina Kusmartseva, Amanda L. Posgai, Denise Drotar, Mackenzie Williams, Natalie de Souza, Todd M. Brusko, Maigan Brusko, Clive Wasserfall, Mark Atkinson Verified, Bernd Bodenmiller
| Nature Verified
Abstract The pathogenesis of type 1 diabetes, particularly at autoantibody-positive preclinical stages, remains poorly understood, in part due to limited sample availability. Here we show imaging mass cytometry data of pancreas samples from 88 organ donors, including 28 single and 10 multiple autoantibody-positive donors. We imaged 16 million single-cells using 79 antibodies to characterize β-cell states and the islet–immune interface, correcting for relevant covariates.
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A stratification system for breast cancer based on basoluminal tumor cells and spatial tumor architecture

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By Lasse Meyer, Hartland W. Jackson, Nils Eling, Haithem Dakhli, Peter Schraml, Constanze Elfgen, Zsuzsanna Varga, Holger Moch, Natalie de Souza, Bernd Bodenmiller, Genki Usui, Susanne Dettwiler
| Cell Press Verified
Keywords triple-negative breast cancer breast cancer imaging mass cytometry multiplexed imaging tumor phenotypes spatial single-cell atlas disease recurrence immunotherapy patient stratification Introduction Triple-negative breast cancer (TNBC) is immunohistochemically characterized by the lack of estrogen (ER) and progesterone (PR) receptor expression and no overexpression or gene amplification of HER2.
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The dawn of an era - Nature Methods

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By Natalie de Souza
| Nature Verified
For Nature Methods’ 20th anniversary, our current and past editors reminisce about their favorite papers, initiatives and projects at the journal. Just about every paper that crossed my desk at Nature Methods has a story that goes with it. I find it excruciatingly difficult to single out just one. So, in the spirit of following the editorial gut instinct — which it’s wise to trust, but never in a vacuum and not too much — I’ll tell you about the paper that comes to mind first.
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