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Nayiar Shahid

As seen in: Drug Metabolism and Disposition (ASPET)
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Articles

Development of a Novel HEK293 Cell Model Lacking SLC29A1 to Study the Pharmacology of Endogenous SLC29A2-Encoded Equilibrative Nucleoside Transporter Subtype 2

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By Nayiar Shahid, Christopher R. Cromwell, Basil P. Hubbard, James Hammond
| Drug Metabolism and Disposition (ASPET)
Introduction The SLC29A-encoded family of equilibrative nucleoside transporters (ENTs) mediate the bidirectional flux of nucleosides (and some nucleobases) across cell membranes and are important for the maintenance of intracellular and extracellular nucleoside levels (Boswell-Casteel and Hays, 2017). There are four subtypes of ENT (ENT1–4) that vary in their substrate specificity, inhibitor sensitivity, and subcellular expression (Baldwin et al., 1999; Pastor-Anglada and Pérez-Torras, 2018).
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Development of a novel HEK293 cell model lacking SLC29A1 to study the pharmacology of endogenous SLC29A2-encoded equilibrative nucleoside transporter subtype 2

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By Nayiar Shahid, Christopher R. Cromwell, Basil P. Hubbard, James Hammond
| Drug Metabolism and Disposition (ASPET)
Abstract Equilibrative nucleoside transporters (ENT) mediate the transmembrane flux of endogenous nucleosides and nucleoside analogues used clinically. The predominant subtype, ENT1, has been well characterized. However, the other subtype, ENT2, has been less well characterized in its native milieu due to its relatively low expression and the confounding influence of co-expressed ENT1.
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