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Basil P. Hubbard on Muck Rack

Basil P. Hubbard

As seen in: Nature, Cell Press, Drug Metabolism and Disposition (ASPET)
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Articles

Amino acid-derived ionizable lipids enable inhaled base editing for therapeutic gene correction in the lung

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By Fanglin Gong, Yue Quan Xu, Jingan Chen, Shun Zhang, Songtao Dong, Lauren Healy, Breanna Y. Seto, Tyler Thomson, Yinghua Tang, Ziyan Chen, Andrew Varley, David Chen, Craig Hodges, Amy Wong, Jim C. Hu, Basil P. Hubbard, John F. Engelhardt, Ziying Yan, Bowen Li, Muye Zhou, Krista Antonio
| Nature Verified
Abstract CRISPR-based gene editing holds promise for treating genetic diseases, yet its application to lung disorders has been hindered by the challenges of pulmonary delivery. Inspired by the modularity and biocompatibility of amino acid-derived chemistries, we report the combinatorial synthesis of 960 ionizable lipids incorporating chemically diverse backbones from both proteinogenic and non-proteinogenic α-amino acids.
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CRISPR/Cas technologies for cancer drug discovery and treatment

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By KEVIN WANG, Tiffany Zheng, Basil P. Hubbard
| Cell Press Verified
References 1. Ishino, Y. ... Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product J. Bacteriol. 1987; 169:5429-5433 2. Barrangou, R. ... CRISPR provides acquired resistance against viruses in prokaryotes Science. 2007; 315:1709-1712 3. Horvath, P. ... Diversity, activity, and evolution of CRISPR loci in Streptococcus thermophilus J. Bacteriol. 2008; 190:1401-1412 4. Jinek, M. ...
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Development of a Novel HEK293 Cell Model Lacking SLC29A1 to Study the Pharmacology of Endogenous SLC29A2-Encoded Equilibrative Nucleoside Transporter Subtype 2

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By Nayiar Shahid, Christopher R. Cromwell, Basil P. Hubbard, James Hammond
| Drug Metabolism and Disposition (ASPET)
Introduction The SLC29A-encoded family of equilibrative nucleoside transporters (ENTs) mediate the bidirectional flux of nucleosides (and some nucleobases) across cell membranes and are important for the maintenance of intracellular and extracellular nucleoside levels (Boswell-Casteel and Hays, 2017). There are four subtypes of ENT (ENT1–4) that vary in their substrate specificity, inhibitor sensitivity, and subcellular expression (Baldwin et al., 1999; Pastor-Anglada and Pérez-Torras, 2018).
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