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ArticleOnline nowOpen access Affiliations & Notes 1Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States of America 2Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States of America 3Department of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States of...
Associations between SCFAs and the fecal microbiome GLMs were applied to determine the associations between genus-level gut bacteria and SCFAs after adjusting for age, sex, SIBO, body mass index (BMI), PPI use, and any immunosuppression. We used Q < 0.05 as a reporting threshold and forest plots to visualize the results.
Abstract Immune cells undergo rapid metabolic reprogramming to fuel effector responses. However, whether the metabolic pathways that supply these functions differ between human and mouse immune cells is poorly understood. Using a comparative metabolomics approach, here we show both conserved and species-distinct metabolite alterations in cytokine-activated primary human and mouse natural killer (NK) cells.
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