Nedas Matulionis

Associations between SCFAs and the fecal microbiome GLMs were applied to determine the associations between genus-level gut bacteria and SCFAs after adjusting for age, sex, SIBO, body mass index (BMI), PPI use, and any immunosuppression. We used Q < 0.05 as a reporting threshold and forest plots to visualize the results.

Abstract Immune cells undergo rapid metabolic reprogramming to fuel effector responses. However, whether the metabolic pathways that supply these functions differ between human and mouse immune cells is poorly understood. Using a comparative metabolomics approach, here we show both conserved and species-distinct metabolite alterations in cytokine-activated primary human and mouse natural killer (NK) cells.

Abstract Characterization of cell type emergence during human cortical development, which enables unique human cognition, has focused primarily on anatomical and transcriptional characterizations. Metabolic processes in the human brain that allow for rapid expansion, but contribute to vulnerability to neurodevelopmental disorders, remain largely unexplored.