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Neil Barrett

As seen in: Wiley Online Library, BioRxiv, Cell Reports
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Articles

miR-93-mediated PTEN suppression and CNS-specific T cell exhaustion shape the leukemia niche in infant KMT2A::AFF1+ B-ALL

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By Alasdair Duguid, Camille Malouf, Tom Leah, Leslie Nitsche, Neil Barrett, Owen Smith, Chris Halsey, Katrin Ottersbach
| Cell Reports Verified
Keywords KMT2A::AFF1 acute lymphoblastic leukemia central nervous system immune microenvironment microRNA miR-93 infant leukemia PTEN leptomeninges immune suppression Research topic(s) CP: immunology CP: cancer Introduction Acute lymphoblastic leukemia (ALL) involvement of the central nervous system (CNS) is the most common and most clinically significant extra-medullary site of disease across all age groups.
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Infant acute lymphoblastic leukaemia—Progress from worldwide clinical efforts

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By Neil Barrett, Tanja A. Gruber, Takako Miyamura, Alasdair Duguid
| Wiley Online Library Verified
CONFLICT OF INTEREST STATEMENT All authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. REFERENCES 1, , . Improvements in outcome of childhood acute lymphoblastic leukaemia (ALL) in the UK—a success story of modern medicine through successive UKALL trials and international collaboration. Br J Haematol. 2020; 191(4): 562–567. 2, , , , , , et al.
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Leukaemia cell intrinsic and extrinsic factors cooperate to facilitate the survival and proliferation of KMT2A-rearranged B-ALL in the CNS niche.

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By Alasdair Duguid, Camille Malouf, Leslie Nitsche, Neil Barrett
| BioRxiv
Abstract Infant B-cell acute lymphoblastic leukaemia (B-ALL) is a rare, aggressive entity characterised by KMT2A rearrangements and poor outcomes. One of the unique features of KMT2A-rearranged infant ALL that contributes to these poor outcomes is a particularly high rate of central nervous system (CNS) involvement. There is a broad lack of understanding regarding the molecular processes and immune environment in CNS ALL.
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