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Nia M. Barkum on Muck Rack

Nia M. Barkum

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Articles

A single residue contributes to phosphoinositide regulation of TRPV1 across two binding sites.

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By Benjamin Graham. He, Rose Hudson, Eric N. Senning, Prateeti Varanasi, Nia M. Barkum
| Cell Press Verified
The ion channel TRPV1 is expressed in the peripheral nervous system where it mediates heat sensation and pain signaling. Although an inhibitory binding site for phosphoinositides was identified at the vanilloid site in TRPV1 structures, a mechanism for phosphatidylinositol 4,5-bisphosphate (PI(4,5)P ) to both inhibit and potentiate TRPV1 activity is lacking. This gap in knowledge led us to examine structural and sequence overlap between TRPV1 and the PI(4,5)P binding site of TRPV5.
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