Niall Barron

Abstract Chinese hamster ovary (CHO) cells are used to produce almost 90% of therapeutic monoclonal antibodies (mAbs) and antibody fusion proteins (Fc-fusion). The annotation of non-canonical translation events in these cellular factories remains incomplete, limiting our ability to study CHO cell biology and detect host cell protein (HCP) impurities in the final antibody drug product.

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Berta Capella Roca‡,§1, Nga Lao¶, Niall Barron¶,‖, Padraig Doolan‡ and Martin Clynes‡,§ ‡National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland §SSPC-SFI, Centre for Pharmaceuticals, Dublin City University, Dublin 9, Ireland ¶National Institute for Bioprocessing Research & Training, A94 X099 Dublin, Ireland ‖School of Chemical & Bioprocessing Engineering, University College Dublin, Belfield, Dublin 4, D04V1W8, Ireland ↵1 To whom correspondence should be...