Nicholas Barringer

Abstract Foot marches are a common occupational task for service members and require walking long distances while carrying heavy occupational loads (e.g., 25 kg fighting load). The physical exertion associated with foot marches may induce sweat-related dehydration and altered thermoregulation, potentially leading to impaired performance and increased risk of exertional heat illness. Yet, many studies fail to assess hydration, even in controlled settings.

Abstract Unraveling the complex associations between human phenotypes and molecular pathways can pave the way to improved health and performance, but faces a fundamental challenge: the measurable genes, proteins, and metabolites vastly outnumber the participants in even the largest studies, yielding spurious correlations.

Conflicts of Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. References 2021. “Circadian Rhythms and the HPA Axis: A Systems View.” WIREs Mech Dis, 13, no. 4 (July): e1518. https://doi.org/10.1002/wsbm.1518. 2006. “Testosterone and Human Aggression: An Evaluation of the Challenge Hypothesis.” Neuroscience & Biobehavioral Reviews 30, no. 3: 319–345.