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Ernest Fraenkel

As seen in: Nature, Wiley Online Library, BioRxiv, Cell Press
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Articles

Single-cell RNA profiling of oligodendroglial lineage cells derived from iPSCs carrying Parkinson’s disease-relevant LRRK2-G2019S mutation

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By Nasser Karmali, Wiebke Kessler, Mohammad Dehestani, Wenhua Sun, Layla Drwesh, Polina Volos, Stanislav Tsitkov, Ashutosh Dhingra, Christian Thomas, Salvador Rodriguez-Nieto, Julia Tietz, David Schafflick, Noémia Fernandes, Julia Fitzgerald, Ernest Fraenkel, Thomas Gasser, Nisha Mohd Rafiq, Tanja Kuhlmann, Vikas Bansal
| Cell Press Verified
ArticleVolume 29, Issue 7116368Open access Affiliations & Notes 1German Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany 2Interfaculty Institute of Biochemistry, University of Tübingen, 72076 Tübingen, Germany 3Institute of Neuropathology, University Hospital Münster, 48149 Münster, Germany 4Hertie Institute for Clinical Brain Research, University of Tübingen, 72076 Tübingen, Germany 5Graduate Training Centre of Neuroscience (GTC), University of Tübingen, 72076 Tübingen,...
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Integration of multiomic and multi-phenotypic data identifies biological pathways associated with physical fitness - Communications Biology

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By Azar Alizadeh, John Graf, Andrew Burns, Fiona Ginty, Kevin O’Donovan, J. Kenneth Wickiser, Nicholas Barringer, Brian Davis, Christine Surrette, Peter Tu, Justin Welch, Ralf Lenigk, Tyler C. Hammond, Sara Peterson, Stephanie Stacey Verified, Scott Evans, Rui Xu, Gurvinder S Khinda, Eric Williams, Nhan Huynh, Ernest Fraenkel, Luca Marinelli, Matthew J. Misner, Gregory Freisinger, Neil Herm Hermansen, J. Elizabeth McDonough, Evelina R. Loghin, Oliver Boomhower, Rachel Sorrell, Alison Caron, Leila Safazadeh, Chrystal Chadwick, James Jobin, Swapnil Chhabra, Taisha Joseh
| Nature Verified
Abstract Unraveling the complex associations between human phenotypes and molecular pathways can pave the way to improved health and performance, but faces a fundamental challenge: the measurable genes, proteins, and metabolites vastly outnumber the participants in even the largest studies, yielding spurious correlations.
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[2508.18638] Biologically Disentangled Multi-Omic Modeling Reveals Mechanistic Insights into Pan-Cancer Immunotherapy Resistance

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By Ernest Fraenkel
| arxiv.org
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