Nicholas Bradshaw

Abstract An emerging area of research into major mental illnesses is to investigate the formation of insoluble aggregates of specific proteins in the brains of patients with these conditions. These studies are normally based on examining insoluble protein in post mortem brain samples, but, for practical reasons, typically consider only one region of the brain per subject.

Correction to: Cancer Gene Therapy https://doi.org/10.1038/s41417-023-00708-w, published online 12 December 2023 In Fig. 2 of this article was cut off at the right side. The figure should have appeared as shown below. The original article has been corrected. About this article Batel, A., Polović, M., Glumac, M. et al. Correction: SPRTN is involved in hepatocellular carcinoma development through the ER stress response. Cancer Gene Ther (2024).

Abstract Endoplasmic reticulum (ER) stress, prompted by the accumulation of misfolded or unfolded proteins, triggers the activation of the unfolded protein response (UPR) pathway to restore ER homeostasis. This stress response is implicated in the development of hepatocellular carcinoma (HCC). A biallelic mutation in SPRTN is currently the only known single-gene mutation implicated in the early onset of HCC. However, the exact mechanism linking SPRTN mutations to HCC remains unclear.