Nicolas André
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Articles by Nicolas André
French Tax on Evergreening Practices: Uncertainties Remain for Pharma Companies
France's so-called "evergreening tax" has been in force since December 31, 2025, but significant uncertainties remain as to its scope and practical application, with no administrative guidance issued to date. The draft 2027 Social Security Financing Bill, published on October 1, 2026, contains, in its current form, no provisions relating to the tax.
Lessons from the Fourth Metronomic and Anti-angiogenic Therapy Meeting, 24–25 June 2014, Milan
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Dynamic electron radiation belt at Mercury controlled by solar wind driving
Abstract Electron radiation belts, reservoirs of stably trapped energetic electrons hazardous to space technology, are a prevalent feature of most magnetized planetary environments. However, their existence in the compact magnetosphere of Mercury has been a subject of debate for decades. The presence of energetic electrons was first identified by Mariner 10’s observations in the 1970s but was subsequently questioned by MESSENGER’s limited energetic particle measurements 40 years later.
Kevin Wilcock - Concurrences
Kevin Wilcock is a European counsel at Jones Day based in the firm’s Düsseldorf office. His practice primarily focuses on antitrust and competition law matters, both at the national and international levels. He advises major national and international companies in their proceedings with the European Commission and the National Competition Authorities of EU Member States.
France Establishes a Restricted Confidentiality Regime for In-House Legal Advice | JD Supra
In Short The Situation: Until now, legal consultations prepared by in-house counsel were not protected under any statutory confidentiality regime in France, unlike correspondence between lawyers and their clients. This gap left internal legal communications exposed to seizure in civil, commercial, or administrative proceedings.
French Supreme Court Adopts New Interpretation of Attorney-Client Privilege | JD Supra
In a decision dated October 8, 2025 (No. 24-16.995), the Commercial Chamber of the French Supreme Court (Cour de cassation) adopted a broader interpretation of attorney-client privilege, departing from the more restrictive approach recently taken by the Criminal Chamber.
M‐Shell and Local Time Variability of the Electron and Magnetic Environments at the Orbit of Callisto as Observed by the Juno and Galileo Missions
Article Dans Une Revue Journal of Geophysical Research Space Physics Année : 2025 M‐Shell and Local Time Variability of the Electron and Magnetic Environments at the Orbit of Callisto as Observed by the Juno and Galileo Missions Domaines Fichier principal JGR Space Physics - 2025 - Le Liboux - M‐Shell and Local Time Variability of the Electron and Magnetic Environments at the.pdf (4.43 Mo) Télécharger le fichier Origine Publication financée par une institution hal-05198671 , version 1...
Striped Hair Colour Change on Tovorafenib in an 18‐Year‐Old Boy With a Brainstem Low‐Grade Glioma
Use the link below to share a full-text version of this article with your friends and colleagues. Learn more. I have read and accept the Wiley Online Library Terms and Conditions of Use I have read and accept the Wiley Online Library Terms and Conditions of Use The authors declare they have no conflicts of interest. Data sharing is not applicable to this article as no new data were created or analyzed in this study. • , , , et al., “ LOGGIC/FIREFLY-2: A Phase 3, Randomized Trial of Tovorafenib vs.
Hematological ratios as an indicator of severity in alopecia areata: A retrospective nationwide study
Discussion Our study represents the first of its kind in analyzing a comprehensive array of hematological ratios within such a large cohort. While the NLR was statistically higher in AA patients, we believe that the ELR was a more robust ratio for distinguishing AA patients from matched controls, as its odds ratio was greater than that of the NLR.This trend was largely consistent when assessing ratios in individuals 12 to 18 months before AA diagnosis.
Exploring ethnic disparities in pediatric molluscum contagiosum in Southern Israel - Scientific Reports
Abstract Molluscum contagiosum (MC) is a common skin infection affecting children globally, including in Israel, which has a diverse population comprising mainly Jews (73.2%) and Arabs (21.1%). Despite documented disparities in various diseases between these groups, research on differences in dermatological care is scarce. This study aimed to investigate MC as a potential differentiator between Arab and Jewish children.
Correction: Bailey et al. Clinical Trials in High-Risk Medulloblastoma: Evolution of the SIOP-Europe HR-MB Trial. Cancers 2022, 14, 374
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Examining the benefits of extended patch test series in children: a comprehensive analysis
The growing presence of allergens in materials and scarce data on allergic contact dermatitis in children has increased our need to refine its diagnosis in this population. We aimed to analyze children's specific responsivity to highly reactive subcomponents of Fragrance mix I, Fragrance mix II, and Textile dye mix from the European baseline series.
Escape and precipitation of planetary ions at Mercury under different solar wind conditions
Communication Dans Un Congrès Année : 2022 Escape and precipitation of planetary ions at Mercury under different solar wind conditions Origine : Fichiers produits par l'(les) auteur(s) insu-04451714 , version 1 (11-02-2024) Sae Aizawa, Nicolas André, Moa Persson, Ronan Modolo, Jim Raines, et al.. Escape and precipitation of planetary ions at Mercury under different solar wind conditions. 16th Europlanet Science Congress 20, Sep 2022, Granada, Spain. pp.EPSC2022-902, ⟨10.5194/epsc2022-902⟩.
Exploring the relationship between allergic contact dermatitis and atopic dermatitis in children: insights from a retrospective patch testing analysis
Introduction The link between allergic contact dermatitis (ACD) and conditions like atopic dermatitis (AD) is uncertain.1, 2 Some sources suggest increased ACD due to AD's impaired skin barrier,3 while others argue AD's Th2 profile might counter Th1-driven ACD development.3 Clinically, Fortina et al.4 identified that 61% of children under the age of 3 with AD exhibited a reaction to at least one sensitizer present in standard patch test baselines.
AcSé-ESMART, a European precision cancer medicine proof-of-concept platform trial - Nature Medicine
The advent of precision cancer medicine has brought considerable promise of improving outcomes for patients with advanced cancer. Molecular profiling of malignancies after treatment failure aims to match patients to subsequent treatment, depending on the molecular profile at recurrence. In this way, improved outcomes have been achieved in small subgroups of patients whose cancers exhibit targetable oncogenic drivers1.
Common Sense Oncology: including everyone
Making room for common sense in oncology brings attention back to patients and both daily and key clinical decisions. I feel that the vision and guidelines proposed by Christopher M Booth and colleagues 1 Booth CM Sengar M Goodman A et al. Common Sense Oncology: outcomes that matter. in the Common Sense Oncology (CSO) movement represent a genuine step forward for oncology. While reading this thought-provoking Comment, however, I was frustrated that there was no mention of paediatric oncology.
Symptom Screening in Pediatrics Tool in children and adolescents with high-risk malignancies: a pilot study
Abstract Objective Childhood and adolescent cancer can result in high burden of distressing symptoms, particularly in high-risk malignancies. The Symptom Screening in Pediatrics Tool (SSPedi) is a reliable and valid approach to measure bothersome symptoms in paediatric patients receiving cancer treatments. Objective was to describe the feasibility of using SSPedi administration among paediatric patients with high-risk malignancies.
U.S. Treasury And OECD Lay Groundwork For Selling Clean Energy Tax Credits
In Short The Situation: With the Inflation Reduction Act of 2022 (the "IRA"), Congress created new tax credits and expanded several others to encourage U.S. taxpayers to invest in clean energy and carbon reduction projects. Congress also provided a framework for taxpayers to buy and sell many of these credits, paving the way for developers to turn these tax credits into cash.
U.S. Treasury and OECD Lay Groundwork for Selling Clean Energy Tax Credits
In Short The Situation: With the Inflation Reduction Act of 2022 (the "IRA"), Congress created new tax credits and expanded several others to encourage U.S. taxpayers to invest in clean energy and carbon reduction projects. Congress also provided a framework for taxpayers to buy and sell many of these credits, paving the way for developers to turn these tax credits into cash.
U.S. Treasury and OECD Lay Groundwork for Selling Clean Energy Tax Credits | JD Supra
In Short The Situation: With the Inflation Reduction Act of 2022 (the "IRA"), Congress created new tax credits and expanded several others to encourage U.S. taxpayers to invest in clean energy and carbon reduction projects. Congress also provided a framework for taxpayers to buy and sell many of these credits, paving the way for developers to turn these tax credits into cash.
Mammary‐analog secretory carcinoma in children: Surgery or TRK inhibitors first?
Abstract We report two cases of pediatric mammary-analog secretory carcinoma (MASC), a male operated on at age 8 and a female operated on at 12, who are in remission 2 years after surgery. The diagnosis of MASC was challenging and established by identifying the ETV6::NTRK3 fusion transcript in both cases.
Access to new drugs in paediatric oncology: can we learn from the ongoing ONC201 saga?
New drugs are the cornerstone to improving survival among children with cancer. For high-grade glioma, only four drugs have been licensed in the past four decades; of which three are still in production (bevacizumab, lomustine, and carmustine). All were selected to overcome both the blood–brain barrier and resistance to chemotherapy and targeted therapies.
French National Financial Prosecutor's Office Publishes New Guidelines on Judicial Conventions of Public Interest | JD Supra
January 31, 2023 Nicolas André, Bénédicte Graulle, Vincent Ohannessian Jones Day + Follow x Following x Following - Unfollow Contact To embed, copy and paste the code into your website or blog: The new guidelines update those published jointly by the National Financial Prosecutor's Office (Parquet National Financier or "PNF") and the French Anticorruption Agency (Agence Française Anticorruption or "AFA") on June 26, 2019.
French National Financial Prosecutor's Office Publishes New Guidelines on Judicial Conventions of Public Interest
The new guidelines update those published jointly by the National Financial Prosecutor's Office (Parquet National Financier or "PNF") and the French Anticorruption Agency (Agence Française Anticorruption or "AFA") on June 26, 2019. They provide more predictability and legal certainty in the implementation of judicial conventions of public interest (conventions judiciaires d'intérêt public, or "CJIPs").
Adjuvant metronomic chemotherapy for locoregionally advanced nasopharyngeal carcinoma
It is a golden age for cancer drug development. There are frequent announcements of regulatory approvals of new drugs, or more commonly, an existing but fairly new drug or drug combination for yet another indication. Immune checkpoint inhibitors and antibody drug conjugates are among the most common of such recent approvals.
France Expanding Tax Permanent Establishment Definition, Overturning Previous Case Law | JD Supra
In Short The Situation: In December 2020, the French administrative supreme court issued a major decision expanding the permanent establishment ("PE") concept and criteria for both French corporate income tax ("CIT") and value-added tax ("VAT") purposes.
France Expanding Tax Permanent Establishment Definition, Overturning Previous Case Law
France: France Expanding Tax Permanent Establishment Definition, Overturning Previous Case Law 07 April 2021 by Nicolas André , Lodewijk Berger , Emmanuel De La Rochethulon , Edward Kennedy and Niv Tadmore Jones Day Your LinkedIn Connections with the authors To print this article, all you need is to be registered or login on Mondaq.com.
Mesothelioma in children and adolescents: the European Cooperative Study Group for Pediatric Rare Tumors (EXPeRT) contribution
Highlights • Large retrospective international study of European pediatric mesothelioma. • Pediatric malignant mesothelioma mainly occurs in adolescents. • Few asbestos exposures in pediatric patients and frequent metastasis. • Possible efficacy of pemetrexed-cisplatinum regimen. • Favorable outcome, particularly in peritoneal primary. Abstract Introduction Very little is known about the characteristics of mesothelial tumours in the paediatric population.
Impact of COVID-19 in Paediatric Early Phase Cancer Clinical Trials in Europe: A report from the Innovative Therapies for Children with Cancer consortium (ITCC)
Highlights • The COVID-19 pandemic has profoundly disrupted paediatric cancer clinical research. • A drastic drop in recruitment in phase I/II trials compared to 2019 was observed. • Current research needs reorganization to avoid loss of opportunities for children. Abstract Introduction Data regarding real-world impact on cancer clinical research during COVID-19 are scarce.
First step toward high‐intensity end‐of‐life care definition in pediatric oncology: Response to bereaved parents' views on end‐of‐life care for children with cancer: Quality marker implications
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Metronomic Maintenance for High-Risk Pediatric Malignancies: One Size Will Not Fit All
Highlights Maintenance treatment is a type of treatment that is delivered to prevent tumor progression after it has been controlled successfully with the initial therapy. The addition of maintenance after completion of standard chemotherapy has been proved to increase survival in some leukemias and solid tumors in children. Maintenance therapy relies mostly on the use of low-dose metronomic chemotherapy.
Challenges and opportunities for cancer clinical trials in low- and middle-income countries
Low- and middle-income countries share the greatest burden of cancer mortality globally but lag behind high-income countries in terms of clinical trials. Here we discuss the challenges facing low- and middle-income countries and the opportunities for conducting trials of affordable, accessible and effective interventions relevant to the local population. Fig. 1: Identifying opportunities for co-development from the perspective of HICs and LMICs. References 1.
Molecular Guided Therapy Provides Sustained Clinical Response in Refractory Choroid Plexus Carcinoma
Introduction In January 2011, a 4 month old female presented with increased emesis and a bulging fontanelle and was diagnosed with Choroid Plexus Carcinoma (CPC) in the right ventricle with metastatic tumor cells present in the cerebral spinal fluid (CSF) and leptomeningeal carcinomatosis.
Metronomic Chemotherapy: Direct Targeting of Cancer Cells after all?
The field of energy metabolism in cancer biology is growing quickly. As a result, the regulation of metabolism is currently emerging as a strategy of choice to control tumor progression [37xHow does metabolism affect cell death in cancer?. Villa, E. and Ricci, J.E. FEBS J. ; 283: 2653–2660 Crossref | PubMed | Scopus (6) | Google ScholarSee all References[37]. Recent studies have shown that MC could impact tumor metabolism. For example, Yapp et al.
Invitation to a Dialogue: Attitudes About Aging
Deeply respecting Pope Francis, I was taken aback when a couple of months ago he criticized Europe as “a ‘grandmother,’ no longer fertile and vibrant.” By slipping into this prejudice despite his valiant condemnation of so many others, the pope reminds us just how pervasive biases about aging are. His comment crystallizes issues about ageism in particular and stereotypes in general that are hard to resolve.
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