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Neoadjuvant chemoradiotherapy with radiation dose escalation with contact x-ray brachytherapy boost or external beam radiotherapy boost for organ preservation in early cT2-cT3 rectal adenocarcinoma (OPERA): a phase 3, randomised controlled trial - The Lan
Background Organ preservation after reaching clinical complete response on neoadjuvant therapy is gaining interest for rectal cancers, although the role of radiation dose escalation is still not known. We aimed to determine whether a contact x-ray brachytherapy boost, following or preceding neoadjuvant chemoradiotherapy, increases the probability of 3-year organ preservation for patients with early rectal cancers.
Planned organ preservation for early T2-3 rectal adenocarcinoma: A French, multicentre study
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Fig. 1 Study treatment and follow-up protocol. *According to tumour response at time of evaluation: follow-up (surveillance) or surgery (TME or local excision). Tt, treatment; D, day; CRT, chemoradiotherapy; EBRT, external beam radiotherapy; w, week. Fig. 2 Patient care pathway.
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