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Articles

mini-Complexome Profiling (mCP), an FDR-controlled workflow for global targeted detection of protein complexes

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By Hugo Amedei, Niels Benjamin Paul, Brian Foo, Lisa Neuenroth
| biorxiv.org
Abstract Introduction: Co-fractionation mass spectrometry couples native-like separations of protein/protein complexes with mass spectrometric proteome analysis for global characterization of protein networks. The technique allows for both de novo detection of complexes and for the detection of subtle changes in their protein composition.
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The importance of DNA sequence for nucleosome positioning in transcriptional regulation

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By Malte Sahrhage, Niels Benjamin Paul, Tim Beissbarth, Martin Haubrock
| biorxiv.org
Abstract Nucleosome positioning is a key factor for transcriptional regulation. Nucleosomes regulate the dynamic accessibility of chromatin and interact with the transcription machinery at every stage. Influences to steer nucleosome positioning are diverse, and the according importance of the DNA sequence in contrast to active chromatin remodeling has been subject of long discussion.
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The importance of DNA sequence for nucleosome positioning in the process of transcriptional regulation

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By Malte Sahrhage, Niels Benjamin Paul, Tim Beissbarth, Martin Haubrock
| biorxiv.org
Abstract Nucleosome positioning is a key factor in the regulation of transcription, as nucleosomes regulate the dynamic accessibility of chromatin for transcription factor binding and interact with the transcription machinery at every stage. Influences to steer nucleosome positioning are diverse, and the importance of the DNA sequence for this process in contrast to active chromatin remodeling has been the subject of a long discussion.
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