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Tim Beissbarth on Muck Rack

Tim Beissbarth

As seen in: JAMA (The Journal of the American Medical Association), BioRxiv
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Articles

CODEX: COunterfactual Deep learning for the in-silico EXploration of cancer cell line perturbations

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By Stefan Schrod, Helena U. Zacharias, Tim Beissbarth, Anne-Christin Hauschild
| BioRxiv
Abstract Motivation: High-throughput screens (HTS) provide a powerful tool to decipher the causal effects of chemical and genetic perturbations on cancer cell lines. Their ability to evaluate a wide spectrum of interventions, from single drugs to intricate drug combinations and CRISPR interference, has established them as an invaluable resource for the development of novel therapeutic approaches.
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The importance of DNA sequence for nucleosome positioning in transcriptional regulation

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By Malte Sahrhage, Niels Benjamin Paul, Tim Beissbarth, Martin Haubrock
| BioRxiv
Abstract Nucleosome positioning is a key factor for transcriptional regulation. Nucleosomes regulate the dynamic accessibility of chromatin and interact with the transcription machinery at every stage. Influences to steer nucleosome positioning are diverse, and the according importance of the DNA sequence in contrast to active chromatin remodeling has been subject of long discussion.
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The importance of DNA sequence for nucleosome positioning in the process of transcriptional regulation

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By Malte Sahrhage, Niels Benjamin Paul, Tim Beissbarth, Martin Haubrock
| BioRxiv
Abstract Nucleosome positioning is a key factor in the regulation of transcription, as nucleosomes regulate the dynamic accessibility of chromatin for transcription factor binding and interact with the transcription machinery at every stage. Influences to steer nucleosome positioning are diverse, and the importance of the DNA sequence for this process in contrast to active chromatin remodeling has been the subject of a long discussion.
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