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Nigmat Rahim on Muck Rack

Nigmat Rahim

As seen in: Nature
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Articles

CD73 inhibitor enhances the antitumor activity of selinexor in multiple myeloma by restoring the activation of CD8 + T cells

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By Chunli Zhang, Qiuxia Wei, Gang Bian, Chaoling Wu, Jing L. Wang, Ping Yang, Jiahui Hua, Mingxia Zhu, Yingtong Chen, Yan Liu, Shuang Gao, Bing Hou, Weilong Zhang, Hongmei Jing, Nigmat Rahim
| Nature Verified
Abstract Selinexor, a selective nuclear export inhibitor, blocks exportin-1 and reduces oncoprotein messenger RNA translation, and is approved for the treatment of relapsed/refractory multiple myeloma in combination with proteasome inhibitors, immunomodulators, anti-CD38 antibodies, etc. Nevertheless, selinexor presents limited monotherapy efficacy with an objective response rate of 29% and fails to completely overcome drug resistance.
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