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Yingtong Chen

As seen in: Nature, Wiley Online Library, Frontiers, MDPI, Canadian Journal of Infectious Diseases & Medical Microbiology, Asian Nursing Research
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Articles

CD73 inhibitor enhances the antitumor activity of selinexor in multiple myeloma by restoring the activation of CD8 + T cells

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By Chunli Zhang, Qiuxia Wei, Gang Bian, Chaoling Wu, Jing L. Wang, Ping Yang, Jiahui Hua, Mingxia Zhu, Yingtong Chen, Yan Liu, Shuang Gao, Bing Hou, Weilong Zhang, Hongmei Jing, Nigmat Rahim
| Nature Verified
Abstract Selinexor, a selective nuclear export inhibitor, blocks exportin-1 and reduces oncoprotein messenger RNA translation, and is approved for the treatment of relapsed/refractory multiple myeloma in combination with proteasome inhibitors, immunomodulators, anti-CD38 antibodies, etc. Nevertheless, selinexor presents limited monotherapy efficacy with an objective response rate of 29% and fails to completely overcome drug resistance.
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BIRC5 drives cell-cycle dysregulation and represents a novel molecular target in retinoblastoma

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By Yingtong Chen, Xiaohan Li, Fuhua Zhong, Xiaoya Wang, Qiang Wang, Di Cao, Shaowei Dong, Chengyue Zhang, Huibin Song, Chen Lin Verified
| Frontiers
Abstract Aims and objectives: Retinoblastoma is the most common pediatric intraocular malignancy, although it remains a rare disease overall, yet the molecular targets and therapeutic vulnerabilities sustaining its most aggressive proliferative cell states remain incompletely defined. We aimed to identify actionable molecular regulators and potential therapeutic targets of malignant retinoblastoma progression using integrated single-cell transcriptomics and functional validation.
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Kinesiophobia and physical activity in patients after percutaneous coronary intervention: the mediating role of self-efficacy and the moderating role of type D personality

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By Yingtong Chen, Minjuan Xie, Ruinan Xia, Jingfang Xiao, Junfeng Zhang, Rui Wang, Xiuhong Weng
| Asian Nursing Research Verified
Research ArticleArticles in PressOpen access 1School of Nursing, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China 2Nursing Department, Hospital of Zhongluotan Town Baiyun District Guangzhou, Guangzhou, Guangdong, China 3Nursing Department, Traditional Chinese Medical Hospital of Huangpu District, Guangzhou, Guangdong, China 4Nursing Department, Dongguan Songshan Lake Central Hospital, Dongguan, Guangdong, China 5Department of Cardiology, the First Affiliated Hospital of...
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