Nikorn Thongthip

Fluorinated molecules play an important role in the process of drug discovery. In fact, the unique properties of fluorine atoms [1], such as their electronegativity and small size, along the C–F bond, make them play a crucial role in medicinal chemistry. Therefore, a large number of marketed drugs contain at least one fluorine atom [[2], [3], [4], [5]].

Traditionally, the chemical industry has relied on alkaline hydrolysis of aromatic benzyl dichloride with sodium hydroxide etc. to produce aromatic benzaldehydes. However, this method suffers from complex synthesis processes, poisonous raw materials involving molecular chlorine, and poor selectivity for benzaldehyde [[1], [2], [3], [4]] to form serious environmental pollution.