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Ninadini Sharma on Muck Rack

Ninadini Sharma

As seen in: Nature, Cell Press
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Articles

Embryo quality control via lineage-specific aneuploid cell elimination in embryos and stem cell-derived embryo models

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By Lisa K Iwamoto-Stohl, Laura Amaya, Pallavi Panda, Yuqi Wang, Ninadini Sharma, Magdalena Zernicka-Goetz
| Nature Verified
Abstract Aneuploidy is frequent in human pre-implantation embryos and a leading cause of early pregnancy loss, yet is rarely observed at birth, implying robust embryonic surveillance. Here we define how this surveillance operates after implantation using an integrated, three-lineage stem cell–derived embryo model that recapitulates the epiblast (EPI), visceral endoderm (VE), and extraembryonic ectoderm (ExE).
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Meiotic Kinetochores Fragment into Multiple Lobes upon Cohesin Loss in Aging Eggs

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By Eirini Bellou, Ninadini Sharma, Ann-Sophie Frombach
| Cell Press Verified
Highlights • Centromeric chromatin in oocytes decompacts as females age • MI/MII kinetochores built on decompacted centromeres fragment into multiple lobes • A partial loss of cohesin is sufficient to mimic these changes in young eggs • Fragmented kinetochores frequently interact incorrectly with spindle microtubules Summary Chromosome segregation errors during female meiosis are a leading cause of pregnancy loss and human infertility.
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