Ninib Baryawno

Abstract Thymic atrophy and the progressive immune decline that accompanies it is a major health problem, chronically with age and acutely with immune injury. No definitive solution is available. Here we demonstrate that one of the three mesenchymal cell subsets identified by single-cell analysis of human and mouse thymic stroma is a critical niche component for T lymphopoiesis.

1. Introduction Renal cell carcinoma (RCC) encompasses a group of malignant tumors originating from the epithelium of the proximal part of the renal tubules. The most prevalent histological subtype is clear cell RCC (ccRCC), accounting for approximately 75–80% of all RCC cases, followed by papillary RCC (pRCC; 10–15%) and chromophobe RCC (5–10%) [1]. Among RCC patients, about one-third develop bone metastasis, with ccRCC being the most common subtype.

Patient materials In accordance with the U.S. Common Rule and after Institutional Review Board (IRB) approval, all human tissues were collected at Massachusetts General Hospital (MGH, Boston, MA) and carried out with institutional review board (IRB) approval (IRB#2003P000641). Written informed consents were obtained from all participants in the study.