Nishant Baruah

Significance Lipid-bilayer membranes compartmentalize biological systems. Similar to translocation through pores, membrane budding controls the exchange of material and information between the compartments. In previous work, an osmotic-pressure difference has been used to drive vesicle-pore translocation; we study translocation driven by the vesicle adhering to a host membrane. Using computer simulations, we predict free, partial-translocated, and complete-translocated states.

Introduction Hello Dev.to community! I'm diving into the intersection of classical data structures and the dynamic world of artificial intelligence (AI), exploring how foundational knowledge in one can propel innovations in the other. Let's embark on this journey together, from the structured realms of Java to the explorative arenas of machine learning (ML), deep learning (DL), and natural language processing (NLP).

Abstract Translocation across barriers and through constrictions is a mechanism that is often used in vivo for transporting material between compartments. A specific example is apicomplexan parasites invading host cells through the tight junction that acts as a pore, and a similar barrier crossing is involved in drug delivery using lipid vesicles on the skin. Here, we use triangulated membranes and energy minimization to study the translocation of vesicles through pores with fixed radii.