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Modulation of lipid nanoparticle-formulated plasmid DNA drives innate immune activation promoting adaptive immunity

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By Nicholas J. Tursi, Sachchidanand Tiwari, Toshitha Kannan, Elizabeth M. Parzych, Nisreen Okba, Kevin Liaw, András Sárközy, Ebony N. Gary, Jennifer Londregan, Mohammad Khan, Serena Omo-Lamai, Hiromi Muramatsu, Casey E. Hojecki, Viviane Machado, Igor Maricic, Trevor Smith Verified, Ami Patel, Andrew V. Kossenkov, Jacob S. Brenner, David Allman, Florian Krammer, Norbert Pardi, David Weiner, Nicole Bedanova, Cory Livingston, Maria Ibanez Trullen, Máté Vadovics, Niklas Laenger, Kerry Blatney, Laurent M. Humeau
| Cell Reports Medicine Verified
Keywords vaccine plasmid DNA lipid nanoparticle DNA-LNP mRNA adjuvanted protein T cell antibody Introduction Vaccine approaches that can elicit both arms of adaptive immunity are valuable tools for combating diverse pathogens as correlates of protection are frequently complex or unvalidated. This is exemplified in an emerging infectious disease scenario, such as the beginning of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.
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