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Nitin Kumar Khandelwal on Muck Rack

Nitin Kumar Khandelwal

As seen in: Nature, ACS Publications, Science Magazine, Royal Society of Chemistry, BioRxiv, Cell Reports, Tax Guru
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Articles

Human CLOCK enhances neocortical function - Nature Neuroscience

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By Nitin Kumar Khandelwal, Connor J Criswell, Joseph S. Takahashi
| Nature Verified
Abstract The transcription factor CLOCK is ubiquitously expressed and important for circadian rhythms, while its human-specific expression in neocortex suggests additional functions. Here, we generated a mouse model (HU) that recapitulates human cortical expression of CLOCK. The HU mice show enhanced cognitive flexibility, which might be associated with alteration in spatiotemporal expression of CLOCK.
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TGF-β inhibitor SB431542 suppresses coronavirus replication through multistep inhibition

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By Assim Verma, Garvit Kumar, Nitin Kumar Khandelwal, Benjamin E. Mayer
| BioRxiv
Abstract The COVID-19 pandemic highlighted the critical need for broad-spectrum antivirals with high resistance barriers. Here, we demonstrate that SB431542, a selective TGF-β receptor I (ALK5) inhibitor, exhibits potent antiviral activity against SARS-CoV-2 through unprecedented multitargeted mechanisms.
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Cell-type-specific roles of FOXP1 in the excitatory neuronal lineage during early neocortical murine development

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By Ana Ortiz, Fatma Ayhan, Nitin Kumar Khandelwal, Elliot H Outland, Matthew Harper, Genevieve Konopka, Miranda Jankovic
| Cell Reports Verified
Keywords Cortical development neurodevelopmental disorders single cell genomics autism spectrum disorder corticogenesis FOXP1 multiomics Research topic(s) CP: Developmental biology CP: Neuroscience Introduction The neocortex is radially organized into layers, each of which is enriched with specialized subtypes of neurons generated from the deepest to superficial layers to form its laminar structure.
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