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Noah Greenwald on Muck Rack

Noah Greenwald

Portland
As seen in: HuffPost, Nature, Yahoo News, Los Angeles Times, The Hill, The Seattle Times, Yahoo, BioRxiv, The News International, The San Diego Union-Tribune and
Endangered Species Program Director for the Center for Biological Diversity.

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Articles

The immunometabolic topography of cellular organization and bacterial control in tuberculosis granulomas - Nature Immunology

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By Erin McCaffrey, Alea Delmastro, Isobel Fitzhugh, Jolene S. Ranek, Sarah Douglas, Joshua Peters, Christine Camacho Fullaway, Marc Bosse, Candace C. Liu, Craig Gillen, Noah Greenwald, Sarah L. Anzick, Craig Martens, Seth Winfree, Yunhao Bai, Cameron Sowers, Mako Goldston, Alex Kong, Potchara Boonrat, Carolyn Bigbee, Roopa Venugopalan, Pauline Maiello, Edwin Klein, Mark Rodgers, Charles A. Scanga, Philana Ling Lin, Sean C. Bendall, Denise Kirschner, Sarah Fortune, Bryan D Bryson, J. Russell Butler, Joshua T Mattila, JoAnne L Flynn, Joanne Flynn, Michael Angelo
| Nature Verified
Abstract Despite being heavily infiltrated by immune cells, tuberculosis (TB) granulomas often subvert the host response to Mycobacterium tuberculosis (Mtb) infection and support bacterial persistence. Human TB granulomas are enriched for immunosuppressive factors typically associated with tumor-immune evasion, raising the possibility that they promote tolerance to infection.
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The automated computational workflow QUICHE reveals structural definitions of antitumor responses in triple-negative breast cancer - Nature Cancer

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By Jolene S. Ranek, Noah Greenwald, Mako Goldston, Christine Camacho Fullaway, Cameron Sowers, Alex Kong, Silvana Mouron, Miguel Quintela-Fandino, Robert West, Sean C. Bendall, Michael Angelo
| Nature Verified
Abstract Recent advances in spatial biology can reveal how tissue organization changes in disease; however, interpreting these datasets in a generalized, scalable way remains challenging. Existing computational approaches rely on pairwise comparisons or unsupervised clustering, which can lack statistical rigor and miss rare, clinically relevant cellular niches.
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Temporal and spatial composition of the tumor microenvironment predicts response to immune checkpoint inhibition in metastatic TNBC - Nature Cancer

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By Noah Greenwald, Iris Nederlof, Cameron Sowers, Daisy Ding, Seongyeol Park, Alex Kong, Kathleen E. Houlahan, Sricharan Reddy Varra, Manon de Graaf, Veerle Geurts, Candace C. Liu, Jolene S. Ranek, Leonie Voorwerk, Michiel de Maaker, Adam Kagel, Erin McCaffrey, Aziz K. Khan, Christine Yeh, Christine Camacho Fullaway, Zumana Khair, Brennan Simon, Yunhao Bai, Hadeesha Piyadasa, Tyler Risom, Alea Delmastro, Felix J. Hartmann, Lise Mangiante, Cristina Sotomayor-Vivas, Sean C. Bendall, Ton N. Schumacher, Zhicheng Ma, Marc Bosse, Robert Tibshirani, Hugo M. Horlings, Christina Curtis, Marleen Kok, Michael Angelo, Marc J. van de Vijver
| Nature Verified
Abstract Immune checkpoint inhibition (ICI) benefits only a subset of patients with metastatic triple-negative breast cancer and determinants of response remain unclear. We assembled a longitudinal cohort of 103 female patients from the phase 2 TONIC trial, with samples spanning primary tumors, pretreatment metastases and on-treatment metastases during nivolumab therapy.
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