Noah S Butler

In a recent publication, Ramalho et al. investigated monocyte-derived dendritic cell (MODC) mobilization in response to Plasmodium infection. The authors showed that elevated levels of itaconate in MODCs results in reduced CD8 T cell activation and that the absence of itaconate is associated with enhanced parasite control.

Isaac J. Jensen, Patrick W. McGonagill, Noah S. Butler, John T. Harty, Thomas S. Griffith and Vladimir P. Badovinac J Immunol March 15, 2021, 206 (6) 1171-1180; DOI: https://doi.org/10.4049/jimmunol.2001131 Key Points NK cells produce IL-10 during sepsis in an IL-15–dependent manner. NK cell–derived IL-10 promotes host survival during sepsis. NK cell–derived IL-10 is relevant to septic patients.

Isaac J. Jensen, Patrick W. McGonagill, Noah S. Butler, John T. Harty, Thomas S. Griffith and Vladimir P. Badovinac J Immunol January 29, 2021, ji2001131; DOI: https://doi.org/10.4049/jimmunol.2001131 Key Points NK cells produce IL-10 during sepsis in an IL-15–dependent manner. NK cell–derived IL-10 promotes host survival during sepsis. NK cell–derived IL-10 is relevant to septic patients.