Nociception Group

1 The Burn Selection Hypothesis For at least one million years, humans — and our extinct relations — have controlled fire [5, 26, 34]. It is often said that this ability was an important factor in our success [33, 34, 111, 92]. The mastery of fire has influenced human culture in many ways.

Highlights Epigenetic changes play a decisive role in the transition from acute to chronic tissue-injury-associated pain by supporting maladaptive molecular changes in neurons and glial cells. PTMs at histone tails are of particular importance. They modulate pain-induced gene transcription by regulating DNA–histone interactions and the binding of other proteins to the chromatin. A shift in HAT/HDAC interactions has been observed in the transition from immediate to lasting pain.