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Noor Momin

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Articles

Tumor-localized interleukin-2 and interleukin-12 combine with radiation therapy to safely potentiate regression of advanced malignant melanoma in pet dogs

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By Noor Momin, Elizabeth Fink, Jordan A Stinson, Allison Sheen
| biorxiv.org
Abstract The clinical use of interleukin-2 and -12 cytokines against cancer is limited by their narrow therapeutic windows due to on-target, off-tumor activation of immune cells when delivered systemically. Engineering IL-2 and IL-12 to bind to extracellular matrix collagen allows these cytokines to be retained within tumors after intralesional injection, overcoming these clinical safety challenges.
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Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy

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By Byong Kang, Noor Momin, Naveen Mehta, Nitasha R. Bennett
| Science Magazine Verified
Download and print this article for your personal scholarly, research, and educational use. Buy a single issue of Science for just $15 USD.
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