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Norimasa Iwanami

As seen in: Cell Reports
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Articles

Lymphocyte-Specific Function of the DNA Polymerase Epsilon Subunit Pole3 Revealed by Neomorphic Alleles

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By of Freiburg, Norimasa Iwanami, Iliana Siamishi, Thomas Clapes
| Cell Reports Verified
Highlights • Pole3 has a non-replicative function during mouse lymphopoiesis • The acidic C terminus of Pole3 regulates the function of the N-terminal domain • Pole3 C-terminal mutants exhibit stage-specific blocks of T and B cell development • Pole3 mutant thymocytes progress faster through the S-phase of the cell cycle Summary Immunodeficiencies are typically caused by loss-of-function mutations in lymphocyte-specific genes.
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By Thomas L. Boehm, Norimasa Iwanami, Katarzyna Sikora, Andreas S. Richter, Maren Mönnich, Lucia Guerri, Cristian Soza-Ried, Divine-Fondzenyuy Lawir, Fernando Mateos, Isabell Hess, Connor P. O’Meara, Michael Schorpp
| secure.jbs.elsevierhealth.com
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