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Nunki Hassan on Muck Rack

Nunki Hassan

As seen in: Cell Press
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Articles

Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia

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By Basit Salik, Hangyu Yi, Nunki Hassan, Nancy Santiappillai
| Cell Press Verified
Highlights • RSPO-LGR4 is essential for stem cell self-renewal in a subset of AML • LGR4 promotes aberrant self-renewal through cooperation with HOXA9 • RSPO3 acts as a stem cell growth factor to sustain proliferation of AML patient blasts • Clinical-grade anti-RSPO3 impairs LSC self-renewal in patient-derived xenografts Summary Signals driving aberrant self-renewal in the heterogeneous leukemia stem cell (LSC) pool determine aggressiveness of acute myeloid leukemia (AML).
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