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Nuno Rocha Nené on Muck Rack

Nuno Rocha Nené

As seen in: Nature, The Journal of Clinical Investigation
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Articles

Immunotherapy drug target identification using machine learning and patient-derived tumour explant validation

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By Marcellus Augustine, Nuno Rocha Nené, Hongchang Fu, Christopher L. Pinder, Lorena Ligammari, Alexander Simpson, Irene Sanz-Fernández, Krupa Thakkar, Danwen Qian, Evelyn Fitzsimons, Benjamin S. Simpson, Roberto Vendramin, Andrea Castro, Samra Turajlic, Sergio A Quezada, Nicholas McGranahan, Chris Watkins, Charles Swanton, Kevin Litchfield, Heather Niederer
| Nature Verified
Abstract Immunotherapy has revolutionized cancer treatment, yet only a minority of individuals respond clinically, necessitating alternative strategies that can benefit these patients. Novel immuno-oncology targets may achieve this through bypassing resistance mechanisms to standard therapies. We introduce Mining Immunotherapy Drug tArgetS (MIDAS), a multimodal graph neural network system for immuno-oncology target discovery.
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