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Nuo Yin on Muck Rack

Nuo Yin

As seen in: Nature, Frontiers in Immunology, European Journal of Obstetrics & Gynaecology and Reproductive Biology
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Articles

Integrated post-GWAS, single-cell, and functional analyses prioritize TCTN2 at an osteoarthritis locus associated with innate immunity-related cartilage remodeling

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By Changchun Lu, Lei Wang, Xinqi Cao, Kun Zhao, Nuo Yin, Dong Zhang
| Frontiers in Immunology
Abstract Background: Post-genome-wide association study (GWAS) interpretation of osteoarthritis (OA) increasingly requires integration with single-cell biology because many risk loci likely act through sterile inflammatory remodeling, regulatory and inflammatory chondrocyte states, and tissue-stress biology rather than through large disease-stage expression shifts.
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Platelet-rich plasma enhances the repair capacity of muscle-derived mesenchymal stem cells to large humeral bone defect in rabbits

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By Yifei Wang, Li Du, Nuo Yin, Junjie Yuan
| Nature Verified
Abstract Mesenchymal stem cell-based therapy is a highly attractive strategy that promotes bone tissue regeneration. The aim of the present study was to evaluate the combination effect of muscle-derived mesenchymal stem cells (M-MSCs) and platelet-rich plasma (PRP) on bone repair capacity in rabbits with large humeral bone defect. Precise cylindrical bone defects of 10 mm diameter and 5 mm depth were established in rabbit humeral bones, which were unable to be repaired under natural conditions.
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