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Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shortening
Highlights • NF-κB is dysregulated in MuSCs of dystrophic mice and DMD patients • Persistent NF-κB activation in MuSCs leads to telomere shortening • Unrestrained NF-κΒ signaling in MuSCs does not alter proliferation • NF-κB activation in MuSCs in chronic injuries leads to Ku80 dysregulation Summary During the repeated cycles of damage and repair in many muscle disorders, including Duchenne muscular dystrophy (DMD), the muscle stem cell (MuSC) pool becomes less efficient at responding to and...
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