Océane Barraud

Visualizing the fat body of D. melanogaster at different developmental stages in 3D D. melanogaster is an important model organism with the characteristics of short life cycle, cost-effectiveness, and ease of manipulation. It has been used in a wide range of applications in genetics and developmental biology, such as carbohydrate, sterol, and lipid metabolism (43, 44). Because of its homology in many enzymes and metabolic pathways with human, most of the D.

The central fiber and its rearrangement upon receptor binding BHPpb3 C-terminal ~210 residues and pb4 N-terminal ~350 residues were modeled de novo (Fig. 1, C and D). As the resolution of the fiber map drops toward the fiber tip because of its flexibility, the rest of pb4 protein was modeled using flexible fitting of the better resolved equivalent domains built in the Tip-FhuA maps (see below and fig. S1H).

Abstract An important paradigm in allogeneic hematopoietic cell transplantations (allo-HCTs) is the prevention of graft-versus-host disease (GVHD) while preserving the graft-versus-leukemia (GVL) activity of donor T cells. From an observational clinical study of adult allo-HCT recipients, we identified a CD4+/CD8+ double-positive T cell (DPT) population, not present in starting grafts, whose presence was predictive of ≥ grade 2 GVHD.