Ogorzalek Loo

Structure-based design of nanobodies that inhibit seeding of Alzheimer’s patient–extracted tau fibrils Romany Abskharon https://orcid.org/0000-0003-1350-0189, Hope Pan https://orcid.org/0000-0001-6509-6224, Michael R. Sawaya https://orcid.org/0000-0003-0874-9043, +23 , Paul M. Seidler https://orcid.org/0000-0001-8530-7244, Eileen J. Olivares https://orcid.org/0000-0003-0627-2405, Yu Chen https://orcid.org/0009-0001-2693-1693, Kevin A.

Mass spectrometry (MS) has become a crucial technique for the analysis of protein complexes. Native MS has traditionally examined protein subunit arrangements, while proteomics MS has focused on sequence identification. These two techniques are usually performed separately without taking advantage of the synergies between them.