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Articles by Ole Hoffstad
Bidirectional Associations Between Seborrheic Dermatitis and Epithelial Barrier Diseases: A Retrospective Cohort Study
1 Introduction Seborrheic dermatitis (SD) is a common dermatologic condition that presents with erythema with overlying greasy scale primarily located on the face, scalp, and other areas with high sebaceous gland activity [1]. SD first occurs in infancy, adolescence, or adulthood, leading to chronic inflammatory skin disease in approximately 5% of the population worldwide [2, 3].
Is Seborrheic Dermatitis of Infancy and Childhood Related to In Utero Exposure to Antibiotics? A Population‐Based Cohort Study From the United Kingdom
Z.C.C.F. has received research grants from Lilly, LEO Pharma, Brexogen, Regeneron, Sanofi, Tioga, and Vanda for work related to atopic dermatitis and from Menlo Therapeutics and Galderma for work related to prurigo nodularis.
The risk of atopic comorbidities and atopic march progression among Black and White children with mild-to-moderate atopic dermatitis: A cross-sectional study
Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with the sequential propagation of atopic comorbidities, such as asthma and allergic rhinitis. This atopic march has been depicted as a homogenous progression of allergic diseases, but patient factors such as race may reveal heterogeneity in this process.
Association of KIR Genes and MHC Class I Ligands with Atopic Dermatitis
David J. Margolis, Nandita Mitra, Ole J. Hoffstad, Brian S. Kim, Dimitri S. Monos and Elizabeth J. Phillips J Immunol September 15, 2021, 207 (6) 1522-1529; DOI: https://doi.org/10.4049/jimmunol.2100379 Key Points AD has been associated with NK cell dysfunction. Individuals with KIR2DS1, KIR2DL5, and KIR2DS5 are more likely to have AD. These KIR genes and KIR-associated HLA epitopes increased the risk of AD.
Association of KIR Genes and MHC Class I Ligands with Atopic Dermatitis
David J. Margolis, Nandita Mitra, Ole J. Hoffstad, Brian S. Kim, Dimitri S. Monos and Elizabeth J. Phillips J Immunol August 18, 2021, ji2100379; DOI: https://doi.org/10.4049/jimmunol.2100379 Key Points AD has been associated with NK cell dysfunction. Individuals with KIR2DS1, KIR2DL5, and KIR2DS5 are more likely to have AD. These KIR genes and KIR-associated HLA epitopes increased the risk of AD. Abstract Atopic dermatitis (AD) is a chronic illness that is associated with immune dysregulation.
Using a Machine Learning Approach to Identify Low-Frequency and Rare FLG Alleles Associated with Remission of Atopic Dermatitis
Atopic dermatitis (AD) is a common relapsing inflammatory skin disease. FLG is the gene most consistently associated with AD. Loss-of-function variants in FLG have been previously associated with AD. Low-frequency and rare alleles (minor allele frequency < 5%) in this gene have been given less attention than loss-of-function variants. We fine sequenced the FLG gene in a cohort of individuals with AD.
Patterns and predictors of atopic dermatitis disease control past childhood: An observational cohort study
Article in Press Patterns and predictors of atopic dermatitis disease control past childhood: An observational cohort study Katrina AbuabaraxKatrina AbuabaraSearch for articles by this authorAffiliationsDepartment of Dermatology, University of California San Francisco (UCSF), San Francisco, CACorrespondenceCorresponding Author: Katrina Abuabara, MD MA. Department of Dermatology, University of California San Francisco (UCSF), 2340 Sutter Street, N421, San Francisco, CA 94115.
Influence of FLG mutations and TSLP polymorphisms on atopic dermatitis onset age
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Atopic dermatitis (AD) is a chronic, inflammatory skin disorder driven by complex biologic and environmental influences.
Persistence of Mild to Moderate Atopic Dermatitis
As with all epidemiologic studies, there are limitations to this report. It is possible that our results do not generalize to all children with AD. Individuals enrolled in the PEER cohort had mild to moderate AD at the time of enrollment that required the use of topical medications (specifically, pimecrolimus) and may have had more severe disease at baseline than those seen in general practice. We were not able to capture incident disease and have only self-reported data on the time of onset.
Response to Comment on Hoffstad et al. Diabetes, Lower-Extremity Amputation, and Death. Diabetes Care 2015;38:1852-1857
We thank van Netten et al. (1) for their kind words about our study (2) and we will try to address their concerns. With respect to Core Outcome Measures in Effectiveness Trials (COMET), as noted in our article, we used a medical record data source of more than 400,000 individuals with diabetes who on average were followed for 9 years (2). More than 6,000 of these individuals had a lower-extremity amputation (LEA).
Epithelial Barrier Diseases Among Adult Patients With Seborrheic Dermatitis
Ayuda Buscar en la ayuda Buscar en la ayuda Epithelial Barrier Diseases Among Adult Patients With Seborrheic Dermatitis Meng, Sabrina [1] ; Berna, Ronald [2] ; Hoffstad, Ole [2] ; Takeshita, Junko [3] ; Shin, Daniel [2] ; Chiesa Fuxench, Zelma C. [2] ; Margolis, David J.
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