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Oliver C. Isaac

As seen in: Cell Chemical Biology
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CXCR4-EGFR heteromers show ligand-dependent changes in conformation and signaling

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By Simon R. Platt, Noemi Karsai, Robert Markus, Marco Siderius, Martine J. Smit, Raimond Heukers, Laura E. Kilpatrick, Stephen Hill, Dehan Comez, Stephanie M. Anbuhl, Oliver C. Isaac
| Cell Chemical Biology Verified
Keywords CXCR4 EGFR receptor oligomerization NanoBRET proximity ligation assays nanobodies Introduction The chemokine CXCR4 receptor and the epidermal growth factor receptor (EGFR) are two cell surface receptors that are overexpressed in different types of cancer including glioblastoma,1,2,3 breast,4 ovarian,5,6 gastric,7 pancreatic,8 and lung9,10 cancer.
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