Simon R. Platt on Muck Rack

Simon R. Platt

As seen in: Arthritis & Rheumatology, Nature, Wiley Online Library, ACS Publications, Journal of Foot and Ankle Research, GamesIndustry.biz, The Drum, Routledge, PocketGamer.biz, Clinician's Brief and
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Articles

Podcast: Seizures, Solutions, & the Human–Animal Bond With Dr. Platt

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By Simon R. Platt
| Clinician's Brief Verified
Audio May 2026 Listen Sponsored Sponsored by PRN Pharmacal Seizures are one of the most emotionally challenging presentations in small animal practice, often leaving veterinarians navigating both urgent medical decisions and distressed owners. In this episode, Dr. Simon Platt joins Dr. Beth to discuss how to approach first-time seizure cases, differentiate idiopathic epilepsy from cases requiring advanced diagnostics, and better support the client experience.
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Cannabinoid CB 2 receptor drives trastuzumab resistance and predicts durable anti-HER2 response

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By Marta Seijo-Vila, Sandra Blasco-Benito, Isabel Tundidor, Maria Rubert-Hernandez, Ana Montero-Calle, Rodrigo Barderas, Laura E. Kilpatrick, Simon R. Platt, Noemi Karsai, Deborah Gomez-Dominguez, Ignacio de Castro Verified, Carmen González-Lois, Antonio J. Sánchez-López, Belén Almoguera Pérez-Cejuela, Luis Manso, Sandra Zazo, Noemi López-Ejeda, Nuria G Martínez-Illescas, María Salazar-Roa, Sonia Castillo-Lluva, Stephen Hill, Manuel Guzman, Eduardo Pérez-Gómez, Cristina Sanchez Verified, Cristina Sánchez, Sofía A. Balsinde, Isabel Philps, Olga M. Antón, Diego García-Fresnadillo, Gala Silvestre-Egea, Esther Ramírez-Medina, Francisco Palomino-Duque, María Turienzo-Durán
| Nature Verified
Abstract Acquired or innate lack of response to standard HER2-targeted therapies remains a clinical issue in patients with HER2-positive breast cancer. Here, we investigated the role of the cannabinoid CB2 receptor (CB2R) in trastuzumab resistance. In human breast cancer samples, a decreased expression of HER2-CB2R heterodimers following neoadjuvant treatment, due to CB2R downregulation, was linked to poor long-term outcomes.
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Two-Step Ligand-Directed Covalent Fluorescent Labeling of the Adenosine A1-Receptor That Maintains Its Orthosteric Binding Site’s Availability to Bind Ligands

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By Chia-Yang Lin, Simon R. Platt, Joelle Goulding, Stephen J. Briddon
| ACS Publications
Chemistry Chemicals and solvents (analytic and HPLC grade) were acquired from commercial suppliers without further purification. trans-Cyclooctene-NHS (TCO-NHS) ester was obtained from Jena Biosciences (Germany). Methyl-tetrazine-sulfoCy5 was purchased from Lumiprobe (Germany), and tetrazine-sulfoCy5 was acquired from BroadPharm (USA). Thin-layer chromatography (TLC) was used to monitor reaction status, and TLC plates were commercial products (Merk Kieselgel 60 F).
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