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Clinical Symptoms and Biomarkers of Cat Allergen-Induced Allergic Rhinitis using the Nasal Allergen Challenge Model
Keywords Allergic rhinitis nasal allergen challenge cat dander Fel d 1 Abbreviations AR (Allergic rhinitis) AR-CIC (Allergic Rhinitis – Clinical Investigator Collaborative) CAC (Cumulative allergen challenge) CBC (Complete blood count) DPR (Dual phase responder) EEU (Environmental Exposure Unit) EPR (Early phase responder) IgE (Immunoglobulin E) LR (Low responder) NAC (Nasal Allergen Challenge) PEPR (Protracted early phase responder) PNIF (Peak nasal inspiratory flow) QOL (Quality of life) SD...
Top Quality Presa Canario Puppies Available Now
harrow, Canada - / Pro Presa Canario / Pro Presa Canario is proud to announce the availability of top-quality Presa Canario puppies, bred with a strong emphasis on health, structure, and temperament. These puppies come from prestigious bloodlines, ensuring that they represent some of the best examples of the breed. The Presa Canario, often recognized as one of the world's best dogs, is known for its loyalty, intelligence, and protective nature, making it an ideal companion for families.
Playful Coconuts
Playful Coconuts creates soul-nourishing travel experiences for adventurous adults who crave connection, curiosity, and a splash of mischief. Adventure. Connection. Fun. At Playful Coconuts, we offer curated, safe, small-group travel experiences with a dash of delight and spontaneity. Our trips are designed for people who want connection, laughter, and unexpected adventures without sacrificing comfort or safety.
Rotational Stagnation Point Non-Newtonian Second-Grade Fluid Flowing over Spiraling Disk
Document Type : Research Article Authors Aamar Abbasi 1 Waseh Farooq 1 Fazle Mabood 2 Asma Tariq 1 Sabir Ali Shehzad 3 Irfan Anjum Badruddin 4 1 Department of Mathematics, University of Azad Jammu and Kashmir Muzaffarabad 13100, Pakistan 2 Department of Information Technology, Fanshawe College London, ON Canada 3 Department of Mathematics, COMSATS University Islamabad, Sahiwal 57000, Pakistan 4 Department of Mechanical Engineering, College of Engineering, King Khalid University, Asir - Abha...
Activatable Photosensitizers: From Fundamental Principles to Advanced Designs
1 Introduction Photodynamic therapy (PDT) is a minimally invasive treatment modality that induces localized cell death through the interaction of light and photoactive agents called photosensitizers, yielding focal generation of reactive oxygen species (ROS). These ROS are products of electronic transitions incurred by photosensitizers when irradiated with light of an appropriate wavelength and intensity (Figure 1).
The High Arctic is dominated by uncharacterized, genetically highly diverse bacteriophages
Abstract While the Earth's virosphere is estimated to be in the range of 10^31 viral particles, the vast majority of its diversity has yet to be discovered. In recent years, metagenomics has rapidly allowed the identification of viruses, from microenvironments to extreme environments like the High Arctic. However, the High Arctic virome is largely composed of viral sequences that have few, if any, matches to classified viruses in existing databases.
ArcticNet's Arctic Change 2024
Sessions View all the Arctic Change 2024 sessions here! About the Event Hosted in Ottawa, December 9 - 12, 2024, ArcticNet's 5th International Arctic Change Conference (AC2024), a special 20th edition of our Annual Scientific Meeting (ASM) is a hub for Arctic and northern research in Canada. The AC2024 brings together researchers from the natural, health, and social sciences to meet the challenges and opportunities of a rapidly changing Arctic region.
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VariantDetective: an accurate all-in-one pipeline for detecting consensus bacterial SNPs and SVs
Accepted manuscripts are PDF versions of the author’s final manuscript, as accepted for publication by the journal but prior to copyediting or typesetting. They can be cited using the author(s), article title, journal title, year of online publication, and DOI. They will be replaced by the final typeset articles, which may therefore contain changes. The DOI will remain the same throughout.
The neoadjuvant approach in resectable pancreatic ductal adenocarcinoma: lessons learned
Neoadjuvant chemotherapy in resectable pancreatic ductal adenocarcinoma is not currently recommended as standard practice but can be considered for patients at high risk (eg, high CA19-9, systemic symptoms, or nodal disease) or in a clinical trial.The PRODIGE24/CCTG-PA.6 adjuvant trial demonstrated the longest median overall survival reported to date of 53·5 months (95% CI 43·5–58·4) in a select cohort and documented the importance of completing adjuvant therapy.In the real-world setting, up...
Where Silicon Materials Can Replace Perfluoroalkyl Substances
It seems like forever that perfluoroalkyl substances (PFAS) have been under scrutiny by regulatory agencies in the U.S. and EU. But that is not why they are colloquially referred to as forever chemicals. Being chemically and thermally stable, there are limited chemical degradation pathways available for PFAS. Furthermore, being synthetic there is no natural biochemical pathway for nature to digest these materials; so they tend to build up in nature.
Cooperative Threat and Risk Reduction in a New Global Context
Explore the evolving global threat landscape and its implications for Canada at this insightful conference hosted by the Norman Paterson School of International Affairs, alongside esteemed partners: the Barton Chair, the Canadian Defence and Security Network (CDSN), the Stimson Center, and Global Affairs Canada. Understanding New Threats: Delve into the latest global threat environment and its impact on international security.
Development, Acceptability, and Usability of a Virtual Intervention for Vertebral Fractures (VIVA)
This project aimed to develop a Virtual Intervention for Vertebral frActures (VIVA) to implement the international recommendations for the non-pharmacological management of osteoporotic vertebral fractures (VFs), and to test its acceptability and usability.
Access to Heart Failure Services in Canada: Findings of the Heart and Stroke National Heart Failure Resources and Services Inventory
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Effects of semaglutide on risk of cardiovascular events across a continuum of cardiovascular risk: combined post hoc analysis of the SUSTAIN and PIONEER trials
CV risk prediction model As described previously, an identical 3-point composite MACE endpoint was the primary outcome for the LEADER, SUSTAIN 6 and PIONEER 6 CVOTs, and was defined as time to first occurrence of death from CV disease (CVD, including undetermined causes), non-fatal MI or non-fatal stroke [13, 26, 31]. The same endpoint was available for the glycemic efficacy trials (SUSTAIN 1–5, the two SUSTAIN Japanese trials, and PIONEER 1–5 and 7–10).
Farm to Lab Sustainable Silicone Coatings Additives
Until recently the market for green, natural or sustainable chemical additives was somewhat vague with uncertain terminology. Recently, this market driver has become clear - products which are not based on petroleum. he origins for this are the beliefs that petroleum is non-sustainable long term and that a fossil fuel economy is harmful to the Earth we all call home. It seems that the “Covidity of Errors” we have lived through has dramatically reinforced this market driver.
Farm to Lab Sustainable Silicone Coatings Additives
Over my 33 year career (so far) in organomodified silicones, customers have occasionally asked me for green, natural or sustainable products. The early requests were infrequent, usually for very specific circumstances, and somewhat vague with the askers often uncertain what their choice of terminology meant. Recently, these requests are coming more frequently and the queriers clearly want products that are not based on petroleum.
Predictors and microbiology of respiratory and bloodstream bacterial infection in patients with COVID-19: living rapid review update and meta-regression
Abstract Objective To identify risk factors and microbiology associated with respiratory and bloodstream bacterial infection in patients with COVID-19. Methods Data Sources: We searched MEDLINE, OVID Epub and EMBASE for published literature up to February 5, 2021. Study eligibility criteria: Studies including at least 50 patients with COVID-19 in any healthcare setting.
Frontiers | Associations of the BDNF Val66Met Polymorphism With Body Composition, Cardiometabolic Risk Factors, and Energy Intake in Youth With Obesity: Findings From the HEARTY Study | Neuroscience
Introduction The high prevalence of pediatric obesity globally (Di Cesare et al., 2019) poses a serious public health concern given the high and growing social, economic, and health burden associated with this chronic disease (Wellman and Friedberg, 2002), and that obesity and associated health risks track from childhood into adulthood.
Use of cannabis in urological cancer patients: A review to evaluate risk for cancer development, therapeutic use, and symptom management
Shipra Taneja 1. Department of Surgery, Division of Urology, McMaster University, Hamilton, ON, Canada 2. McMaster Institute of Urology, St. Joseph’s Healthcare Hamilton, Hamilton, ON, Canada 3. Urologic Cancer Centre for Research & Innovation, St. Joseph’s Healthcare Hamilton, ON Canada Jen Hoogenes McMaster University Marissa Slaven 1. Juravinski Cancer Centre, Juravinski Hospital, Hamilton, ON, Canada 2. Department of Family Medicine, McMaster University, Hamilton, ON, Canada Anil Kapoor 1.
A Mindfulness Group Intervention in Newly Diagnosed Persons with Multiple Sclerosis: A Pilot Study
Highlights • A new diagnosis of relapsing MS (RMS) can be a highly stressful event • Developing good coping skills may alleviate some of the stress of this diagnosis • Mindfulness is a meditative practice that may improve coping skills in RMS • This pilot study found that the mindfulness group showed improved coping and depression • This benefit, compared to a control group, was not maintained 6 months’ post intervention Abstract Background Relapsing MS (RMS) is a lifelong disease without a...
Postural orthostatic tachycardia syndrome (POTS) and other autonomic disorders after COVID-19 infection: a case series of 20 patients
Skip to main content Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation Journal List Nature Public Health Emergency Collection PMC8009458 Svetlana Blitshteyn1 and Sera Whitelaw2 Svetlana Blitshteyn 1Department of Neurology, State University of New York At Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY USA Sera Whitelaw 2Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON Canada Author information Article...
An expert consensus to standardise clinical, endoscopic and histologic items and inclusion and outcome criteria for evaluation of pouchitis disease activity in clinical trials
ORIGINAL ARTICLE The complete affiliations for all authors are listed in Appendix 1. The Handling Editor for this article was Professor Jonathan Rhodes, and it was accepted for publication after full peer‐review. Summary Background Pouchitis is a condition with large unmet medical needs and no approved therapies. Lack of validated instruments to measure disease activity and treatment response is a major barrier to drug development.
The Ethics of Emotion in Artificial Intelligence Systems
ABSTRACT In this paper, we develop a taxonomy of conceptual models and proxy data used for digital analysis of human emotional expression and outline how the combinations and permutations of these models and data impact their incorporation into artificial intelligence (AI) systems.
Standardisation of intestinal ultrasound scoring in clinical trials for luminal Crohn’s disease
ORIGINAL SCIENTIFIC PAPER Robert V. Bryant Corresponding Author robert.bryant@sa.gov.au Adelaide, SA, Australia Correspondence Christopher Ma, Division of Gastroenterology & Hepatology, Departments of Medicine & Community Health Sciences, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, Alberta, Canada, T2N 4Z6. Email: christopher.ma@ucalgary.ca Robert V. Bryant, The Queen Elizabeth Hospital, 28 Woodville Road, Woodville South, 0511 SA, Australia.
An expert consensus to standardise the assessment of histological disease activity in Crohn's disease clinical trials
ORIGINAL ARTICLE Vipul Jairath Corresponding Author vipul.jairath@robartsinc.com orcid.org/0000-0002-1092-0033 London, ON, Canada Correspondence Vipul Jairath, Professor of Medicine, Division of Gastroenterology, Department of Medicine; Department of Epidemiology and Biostatistics, Western University, London, ON, Canada.
Helping Your Baby Adjust To Daylight Savings Time - Fall Back
When you were young and single, you loved “Fall Back.” The end of daylight savings time helped you sneak in another hour of sleep. As a parent… you might not be so lucky. Daylight Savings Time ends this year on Sunday, November 1st, 2020. The good purpose of daylight savings time was to shift more of that summer sunlight into our night time. Otherwise it would have been bright at 5 am every day. Now in the fall, we end that daylight savings time.
The practice of regional anesthesia during the COVID-19 pandemic: an international survey of members of three regional anesthesia societies
Journal List Nature Public Health Emergency Collection PMC8601752 Language: English | French Vishal Uppal 1Department of Anesthesia, Perioperative Medicine and Pain Management, Nova Scotia Health Authority and IWK Health Centre, Dalhousie University, Halifax, NS B3K 6R8 Canada Harsha Shanthanna 2Department of Anesthesia, McMaster University, Hamilton, ON Canada Hari Kalagara 3Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Jacksonville, FL USA Rakesh V.
The impact of training era on the outcomes of transurethral prostatectomy
Campbell, J. D., Reid, J., Ordon, M., & Welk, B. (2020). The impact of training era on the outcomes of transurethral prostatectomy. Canadian Urological Association Journal , 14 (9), E465-7. https://doi.org/10.5489/cuaj.6204 You, the Author(s), assign your copyright in and to the Article to the Canadian Urological Association.
CoBank Colorado Senior Open - Overall Leaderboard
1 John UrquhartJ. Urquhart Phoenix, AZ -3 5 -3 17 17 2 Gerry NorquistG. Norquist Anthem, AZ -2 3 -2 11 11 T3 David Nelson (a)D. Nelson (a) Littleton, CO -1 3 -1 12 12 T3 Perry HolmesP. Holmes Denver, CO -1 3 -1 12 12 T5 Gary MortaraG. Mortara San Leandro, CA E 7 E 27 27 T5 Jim CarterJ. Carter Scottsdale, AZ E 7 E 27 27 T5 Dave ArbuckleD. Arbuckle Colorado Springs, CO E 3 E 13 13 T5 John RobinsonJ. Robinson Orlando, FL E 3 E 13 13 T5 Bob Schuler (a)B.
Outcomes of Pregnant Women With Cirrhosis and Their Infants in a Population-Based Study
This paper is only available as a PDF. To read, Please Download here. ABSTRACT Background & Aims The incidence of cirrhosis is increasing among women of childbearing age. Contemporary outcomes of pregnant women with cirrhosis and their infants, and liver-related complications, have not been described in North America. We investigated the association between cirrhosis and perinatal outcomes and evaluated perinatal liver-related events.
Implementing a shared decision‐making and cognitive strategy‐based intervention: Knowledge user perspectives and recommendations
SPECIAL ISSUE Kay‐Ann M. Allen BSc Corresponding Author E-mail address: kay-ann.allen@sunnybrook.ca https://orcid.org/0000-0002-3815-1045 St. John’s Rehab Research Program, Sunnybrook Research Institute, Toronto, ON, Canada Correspondence Kay‐Ann Allen, St. John's Rehab Research Program, Sunnybrook Research Institute, Toronto, ON M2M 2G1, Canada. Email: kay-ann.allen@sunnybrook.ca Search for more papers by this author Jennifer A.
Inhaled hypertonic saline in preschool children with cystic fibrosis (SHIP): a multicentre, randomised, double-blind, placebo-controlled trial
Summary Background Inhaled hypertonic saline enhances mucociliary clearance, improves lung function, and reduces pulmonary exacerbations in people with cystic fibrosis older than age 6 years. We aimed to assess the effect of inhaled hypertonic saline on the lung clearance index (LCI 2·5)—a measure of ventilation inhomogeneity—in children aged 3–6 years with cystic fibrosis.
Disrupting gender norms in health systems: making the case for change
1. Weber AM Cislaghi B Meausoone V et al. How gender norms shape health: insights from global survey data. Lancet. 2019; () 2. Heise L Greene M Opper N et al. Gender inequality and restrictive gender norms: framing the challenges to health. Lancet. 2019; () 3. Heymann J Levy JK Bose B et al. Improving health with programmatic, legal, and policy approaches to reduce gender inequality and change restrictive gender norms. Lancet. 2019; () 4. Akseer N Salehi AS Hossain SM et al.
Hyperpolarised 129Xe MRI to monitor treatment response in children with cystic fibrosis
Jonathan H. Rayment, Marcus J. Couch, Nancy McDonald, Nikhil Kanhere, David Manson, Giles Santyr, Felix Ratjen European Respiratory Journal 2019; DOI: 10.1183/13993003.02188-2018 Abstract Pulmonary magnetic resonance imaging using hyperpolarised 129Xe gas (XeMRI) can quantify ventilation inhomogeneity by measuring the percentage of unventilated lung volume (ventilation defect percent; VDP).
The Effect of Cracks on the In‐plane Electrical Conductivity of PEFC Catalyst Layers
The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Full Paper The Effect of Cracks on the In‐plane Electrical Conductivity of PEFC Catalyst Layers M. Tam Structure, Properties and Performance Research Division, Automotive Fuel Cell Cooperation Corporation, , Burnaby, BC, Canada Marvelous Planet Technologies, 501-3292, , Burnaby, BC, Canada Search for more papers by this author J. T.
It’s security, stupid! Voters’ perceptions of immigrants as a security risk predicted support for Donald Trump in the 2016 US presidential election
We analyzed two datasets to determine the predictive validity of four explanations of support for Donald Trump during the 2016 US presidential election: (a) security concerns regarding immigrants, (b) economic concerns regarding immigrants, (c) cultural concerns regarding immigrants, and (d) social dominance orientation.
Repeatability of nasal allergen challenge results - further validation of the allergic rhinitis clinical investigator collaborative (AR-CIC) protocols - Annals of Allergy, Asthma & Immunology
Article in Press Repeatability of nasal allergen challenge results – further validation of the allergic rhinitis clinical investigator collaborative (AR-CIC) protocols, , , , Helen L. NeighbourxHelen L. NeighbourSearch for articles by this authorAffiliationsDivisions of Clinical Immunology & Allergy and Respirology, Department of Medicine, Firestone Institute of Respiratory Health, The Research Institute at St. Joe's Hamilton and McMaster University, Hamilton, ON, Canada, MD PhD, Anne K.
Nuclear magnetic relaxation dispersion of murine tissue for development of T1 (R1) dispersion contrast imaging
This study quantified the spin–lattice relaxation rate (R ) dispersion of murine tissues from 0.24 mT to 3 T. A combination of ex vivo and in vivo spin–lattice relaxation rate measurements were acquired for murine tissue. Selected brain, liver, kidney, muscle, and fat tissues were excised and R dispersion profiles were acquired from 0.24 mT to 1.0 T at 37 °C, using a fast field-cycling MR (FFC-MR) relaxometer.
Chocolate Covered Insects
IMPORTANT: During May through September, we strongly recommend Express Shipping for the Chocolate Covered Insects to reduce the risk of melting. Each package contains six completely edible, farm-raised chocolate covered insects. A truly one-of-a-kind treat for any student brave enough to try them. The truth is we think they taste like chocolate covered popcorn.
Unreliable estimation of prevalence of fetal alcohol syndrome - Authors' reply
We thank Katrine Strandberg-Larsen and colleagues from Denmark and Simona Pichini and colleagues from Italy for their comments on our paper.1 Both comments underline the immense interest in the related public health problems of alcohol use during pregnancy and fetal alcohol syndrome (FAS).With respect to the comment of Strandberg-Larsen and colleagues from Denmark, the authors question our finding that the prevalence of alcohol use during pregnancy in the WHO European Region was estimated to...
Comparing those diagnosed early versus late in their HIV infection: implications for public health
Routine HIV surveillance cannot distinguish between recent and older infections: HIV-positive individuals reported soon or long after infection are both considered new diagnoses from a surveillance perspective, notwithstanding the time since infection. This lack of specificity makes it difficult to understand the jurisdiction-specific trends in HIV epidemiology needed for prevention planning.
Writing peer-reviewed articles with diverse teams: considerations for novice scholars conducting community-engaged research
Given the growth of interdisciplinary and community-engaged health promotion research, it has become increasingly common to conduct studies in diverse teams. While there is literature to guide collaborative research proposal development, data collection and analysis, little has been written about writing peer-reviewed publications collaboratively in teams. This gap is particularly important for junior researchers who lead articles involving diverse and community-engaged co-authors.
Identification of children at risk of influenza-related complications in primary and ambulatory care: a systematic review and meta-analysis
1. Nair H Brooks WA Katz M et al. Global burden of respiratory infections due to seasonal influenza in young children: a systematic review and meta-analysis. Lancet. 2011; 378: 1917-1930 2. Van Kerkhove MD Vandemaele KA Shinde V et al. Risk factors for severe outcomes following 2009 influenza A (H1N1) infection: a global pooled analysis. PLoS Med. 2011; 8: e1001053 3. Belongia EA Irving SA Waring SC et al.
Animals and Mechanisms of Disease Transmission
Bacterial Foodborne Zoonoses Campylobacter sp. and Salmonella sp. are the leading causes of bacterial foodborne zoonoses in the US and European Union from domestic acquisition [7, 13, 14].
The Traumatizing Impact of Racism in Canadians of Colour
Muslim Canadians Muslims represent approximately 3.2% of the Canadian population and are believed to be one of the rapidly increasing ethnoracial and religious minority groups in Canada [101]. Muslim Canadians represent a heterogeneous group of individuals based on factors such as race, ethnicity, gender, culture, economic situation, countries of origin, and national contexts that intersect to inform their experiences [102].
Intense/obsessional interests in children with gender dysphoria: a cross-validation study using the Teacher’s Report Form
Journal List Child Adolesc Psychiatry Ment Health v.11; 2017 PMC5613451 As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health. Learn more about our disclaimer. Kenneth J. Zucker 1Department of Psychiatry, University of Toronto, Toronto, ON M5T 1R8 Canada A.
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