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Ondine Atwa

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Articles

Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure

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By Bridget Simonson, Mark Chaffin, Matthew Hill, Ondine Atwa
| Cell Reports Verified
1 Global epidemiology of ischemic heart disease: results from the global burden of disease study. ICM is most commonly caused by atherosclerotic coronary artery disease inhibiting blood flow to the heart. This leads to decreased oxygen in the myocardium causing cardiomyocyte death and cardiac remodeling via formation of a fibrotic scar. Over time the lack of oxygen and formation of the scar leads to a loss of contractile function, cardiac hypertrophy, dilation, and heart failure.
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