ORALRES Group

1 Introduction The packaging and marketing strategies employed for electronic cigarettes (e-cigs), also known as electronic nicotine delivery systems (ENDS) and heated tobacco products (HTPs), have attracted a lot of attention, becoming common among the young population [1]. This is mainly due to the strong commercial appeal, where the device comes in a variety of designs, colors, and flavorings, as well as producing large amounts of smoke, even without the direct burning of tobacco.

1. Introduction Oral cancer is the most incident type of head and neck cancer. In 2020, lip and oral cavity cancer together accounted for an estimated 377,713 new cases worldwide (40.5% of all new cases of head and neck cancer) (1). Its global annual age-standardized rate (ASR-W) is 4.1 cases per 100,000 population, showing broad variation across regions. Melanesia and South-Central Asia present the highest ASR, while the lowest is found in Western Africa (1).