Ossama Al-Mefty

Abstract Skull base chordomas are rare, locally invasive tumors that remain a diagnostic and therapeutic challenge. We developed a machine-learning (ML) radiomics model to (i) distinguish chordoma from chondrosarcoma and skull base background, (ii) differentiate true postoperative residual tumor from treatment-related changes, and (iii) predict 2-year progression-free survival (PFS). In this retrospective, dual-center study, 61 patients underwent surgery between 1998 and 2023.

Keywords: optic canal; skull base; endoscopic endonasal surgery; optic nerve decompression; optic nerve sheath The optic nerve is beset by intrinsic and extrinsic pathologies attributable to its anatomical milieu. Pathologic lesions may border, compress, encase, or enlarge the nerve, proving difficult to decipher on imaging. Orbital MRI relies on thin-cut, fat-suppressed contrast-enhanced, and T2-weighted images to distinguish the optic nerve from neighboring pathology.

2.5. Anatomy of The Sellar Diaphragm Large and giant pituitary adenomas can be resected with a single endoscopic procedure in less than 50% of cases [85,86,87,88,89]. The sellar diaphragm’s anatomy affects the suprasellar growth pattern of large and giant pituitary adenomas, and the invasion of the subarachnoid space is among the most important limiting factors of the gross total resection [86,89,90,91,92,93].