O’Taveon Fitzgerald on Muck Rack

O’Taveon Fitzgerald

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Articles

Resolution of R-loops and transcription–replication conflicts by SETX–BRCA1–BARD1 complex

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By Arijit Dutta, Jae-Hoon Ji, Shahrez Syed, Qingming Fang, Pramiti Mukhopadhyay, Hanzhou Wang, Daisy Medina, Shahad Abdulsahib, Shuo Zhou, Miriam Tovar, Jeff Wang, Jane M Benoit, Fengshan Liang, Nozomi Tomimatsu, Julius Nyalwidhe, Eloïse Dray, Drew McDonald, Wenjing Li, ane Herrero, Alexander Taylor, YoungHo Kwon, Oliver J. Semmes, Miaw-sheue Tsai, Manjeet K. Rao, Robert A. Hromas, Sandeep Burma, Yidong Chen, Alexander V. Mazin, Elizabeth V. Wasmuth, Shaun K Olsen, Daohong Zhou, Alexander Bishop, Weixing Zhao, Gary M. Kupfer, Patrick Sung Verified, Eva Loranc, Amy Verway-Cohen, Bárbara de la Peña Avalos, O’Taveon Fitzgerald
| Nature Verified
Abstract Senataxin (SETX), an RNA–DNA helicase, accumulates at transcription pause sites through the tumor suppressor BRCA1. Here, we provide mechanistic insight into how SETX–BRCA1 resolves transcription-associated R-loops to prevent deleterious outcomes. Specifically, we show that full-length SETX unwinds R-loops with broad specificity and that the complex of BRCA1 and its obligatory partner BARD1 binds R-loops and stimulates R-loop unwinding by SETX.
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