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Articles

Temporal proteomic and phosphoproteomic dynamics during neuronal differentiation in the reference iPSC line KOLF2.1J

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By Ying Hao, Qianqian Cao, Erica M. Periandri, Ziyi Li, Daniel Ramos, Marianita Santiana, Benjamin Jin, Jacob Epstein, Jasmin Camacho, Jae-Hyeon Park, Linda Yang, Jessica Root, Paige Jarreau, Isabelle Kowal, Nicole Carmiol, Aleksandra Beylina, Dylan C. Sacks, Cory A. Wel
| Science Magazine Verified
Editor’s summary Cell lines derived from human induced pluripotent stem cells (iPSCs) have the potential to overcome some of the limitations and challenges of animal models in neurodevelopment and disease research. Hao et al. analyzed the changes in protein abundance and phosphorylation that occurred during neuronal differentiation of the iPSC-derived cell line KOLF2.IJ, which is a proposed neuron model for Alzheimer’s disease and related dementia research.
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