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Palmiero Monteleone

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Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder | Molecular Psychiatry

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By Azmeraw T. Amare, Klaus Oliver Schubert, Janice M. Fullerton, Simon Hartmann, Sergi Papiol, Urs Heilbronner, Bárbara Arias, Joanna M. Biernacka, Hsi-Chung Chen, Sven Cichon, Cristiana Cruceanu, Piotr Czerski, J. Raymond DePaulo, Bruno Etain, Andreas J. Forstner, Mark Frye, Julie Garnham, Fernando S. Goes, Janos L. Kalman, Mojtaba Oraki Kohshour, Eva C. Schulte, Jens Wiltfang, Philipp Ritter, Julia Schmidt, Marius Koch, Joanna Hauser, Po-Hsiu Kuo, Sarah Kittel-Schneider, Ichiro Kusumi, Mikael Landén, Catharina Lavebratt, Marion Leboyer, Alfonso Tortorella, Michael McCarthy, Michael Mccarthy, Francesc Colom, Vincent Millischer, Markus M Nöthen, Tomáš Novák, Claudia Pisanu, Andreas Reif, Eva Z Reininghaus, Guy Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofield, Giovanni Severino, Alessio Squassina, Gustavo Turecki, Eduard Vieta, Stephanie Witt, Peter P. Zandi, Martin Alda, Marcella Rietschel, Francis J. McMahon, Scott Clark Verified, Cynthia Marie-Claire, Maria Del Zompo, Stephane Jamain, Maria Grigoroiu-Serbanescu, Jens Reimer, Cüneyt Yildiz, Kathrin Gade, Palmiero Monteleone, Katzutaka Shimoda, Pavla Stopkova
| Nature Verified
Abstract Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental health disorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consistently effective, with only 30% of patients showing a favorable response to treatment. To provide personalized treatment options for bipolar patients, it is essential to identify prediction biomarkers such as polygenic scores.
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